WBC、GRA%、CRP与PCT在新生儿败血症早期诊断中的应用  

To Explore the Application Value of Blood WBC、GRA%、CRP and PCT in Early Diagnosis of Neonatal Sepsis

作　　者：巫福娟 周成[1] 张李霞[1] 戴怡蘅[1] 高晓燕[1] Wu Fujuan;Zhou Cheng;Zhang Lixia;Dai Yiheng;Gao Xiaoyan(Foshan Women and Children Hospital,Foshan 528000,China)

机构地区：[1]佛山市妇幼保健院新生儿科,广东佛山528000

出　　处：《哈尔滨医药》2022年第3期26-28,共3页Harbin Medical Journal

摘　　要：目的探讨血白细胞(WBC)、中性粒细胞百分比(GRA%)、C反应蛋白(CRP)和降钙素原(PCT)在新生儿败血症早期诊断的应用价值。方法回顾性分析我院收治99例足月新生儿的临床资料,确诊为新生儿败血症的45例患儿为观察组,择同期住院的非感染性患儿54例为对照组,比较两组患儿入院时血WBC、GRA%、CRP、PCT水平,以及观察组患儿治疗前及治疗一周后血WBC、GRA%、CRP、PCT水平,并通过绘制受试者工作特征(ROC)曲线分析WBC、GRA%、CRP、PCT对新生儿败血症早期诊断的价值。结果观察组患儿血WBC、GRA%、CRP、PCT水平高于对照组(P<0.05),观察组患儿治疗一周后血WBC、GRA%、CRP、PCT水平较治疗前降低(P<0.05);血WBC、GRA%、CRP、PCT诊断新生儿败血症的ROC曲线下面积分别为0.722、0.887、0.908、0.964。结论动态监测血WBC、GRA%、PCT、CRP对新生儿败血症治疗有一定参考意义;血WBC诊断价值最低,PCT、CRP、GRA%对早期诊断新生儿败血症有良好的诊断价值。Objective To explore the application value of white blood cell(WBC)neutrophilic granulocyte(GRA%),C-reactive protein(CRP)and procalcitonin(PCT)in early diagnosis of neonatal sepsis.Methods Retrospective and analysis of the clinical data of 99 cases full-term neonates treatedin our hospital,45 children diagnosed with neonatal were sepsiswere served as the observation group,while another 54 non-infectious children hospitalized during the same period were served as the control group.The levels of the blood WBC、GRA%、CRP、PCT were evaluated in each group,both of the levels of the blood WBC、GRA%、CRP、PCTwere evaluated in observation group before and after treatment for one week.Then analyze the application value of WBC、GRA%、CRP、PCT in early diagnosis ofneonatal sepsis by drawing the receiver operating characteristic curve(ROC curve).Results The levels of the blood WBC、GRA%、CRP and PCT in the observation group were higher than those in the control group(P<0.05).The levels of the blood WBC、GRA%、CRP and PCT in the observation group were reduced after treated one week(P<0.05).The area diagnose neonatal sepsis under the ROC curve of WBC,GRA%,CRP and PCT were 0.722,0.887,0.908,0.964,respectively.Conclusion The dynamic monitoring of blood WBC,GRA%,CRP and PCT has a certain reference value for the treatment of neonatal sepsis.The blood WBC has the lowest diagnostic efficiency in diagnose neonatal sepsis,the detection of the PCT,CRP,GRA%has a good diagnostic value for neonatal sepsis.

关 键 词：新生儿败血症 中性粒细胞百分比 降钙素原 C反应蛋白 ROC曲线 

分 类 号：R722.131[医药卫生—儿科]