OSAHS患儿应用鼻内镜下腺样体低温等离子消融术治疗对其免疫功能的影响  

Effects of Nasal Endoscopic Low-Temperature Plasma Ablation of Adenoid on Lmmune Function in OSAHS Children

作　　者：李颖[1] Li Ying(Children's Hospital Affiliated to Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院,河南郑州450003

出　　处：《哈尔滨医药》2022年第2期8-10,共3页Harbin Medical Journal

基　　金：河南省医学科技攻关计划联合共建项目(2018020609)。

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿应用鼻内镜下腺样体低温等离子消融术治疗对其免疫功能的影响。方法选取88例OSAHS患儿,采用简单随机分组将患者分为观察组和对照组,每组各44例。对照组采用腺样体剥离术治疗,观察组采用鼻内镜下腺样体低温等离子消融术治疗。手术后,比较两组患儿治疗效果,采用酶联免疫吸附法测定血清中免疫球蛋白G(IgG)、免疫球蛋白A(IgA)和免疫球蛋白M(IgM);采用贝克曼流式细胞仪检测外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)),观察并记录两组患儿术后并发症的发生情况。结果观察组OSAHS患儿治疗的总有效率(93.18%)与对照组(86.36%)比较差异无统计学意义(P>0.05);术后,观察组血清IgG、IgA及IgM水平和外周血CD3^(+)、CD4^(+)水平、CD4^(+)/CD8^(+)细胞比例均显著高于对照组,差异均有统计学意义(P<0.05)。观察组患儿术后并发症发生率(2.27%)与对照组(11.36%)比较差异无统计学意义(P>0.05)。结论鼻内镜下腺样体低温等离子消融术治疗OSAHS患儿的疗效和并发症方面与鼻内镜下腺样体剥离术治疗方法无异,且对免疫功能影响较小。Objective To explore the effects of nasal endoscopic low-temperature plasma ablation of adenoid on immune function in children with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods A total of 88 children confirmed with OSAHS in the hospital were enrolled.According to simple random grouping method,they were divided into observation group and control group,44 cases in each group.The control group underwent adenoid dissection,while observation group was treated with nasal endoscopic low-temperature plasma ablation of adenoid.After surgery,curative effect between the two groups was compared.The serum immunoglobulin G(IgG),immunoglobulin A(IgA)and immunoglobulin M(IgM)were detected by enzyme linked immunosorbent assay.The peripheral blood T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))were detected by Beckman flow cytometry.The occurrence of postoperative complications in both groups was observed and recorded.Results The difference in total response rate of treatment between observation group and control group was not statistically significant(93.18%vs 86.36%)(P>0.05).After surgery,levels of serum IgG,IgA and IgM,and peripheral blood CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in observation group were significantly higher than those in control group(P<0.05).The difference in incidence of postoperative complications between observation group and control group was not statistically significant(2.27%vs 11.36%)(P>0.05).Conclusion There is no difference in curative effect and complications between nasal endoscopic low-temperature plasma ablation of adenoid and adenoid dissection in the treatment of OSAHS children,with few effects on immune function.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 低温等离子消融术 免疫功能 

分 类 号：R762[医药卫生—耳鼻咽喉科]