Bioefcacy and durability of Olyset® Plus, a permethrin and piperonyl butoxide-treated insecticidal net in a 3-year long trial in Kenya  

作　　者：Paul M.Gichuki Luna Kamau Kiambo Njagi Solomon Karoki Njoroge Muigai Damaris Matoke‑Muhia Nabie Bayoh Evan Mathenge Rajpal S.Yadav 

机构地区：[1]Eastern&Southern Africa Centre of International Parasite Control,Kenya Medical Research Institute,Nairobi,Kenya [2]School of Health Sciences,Meru University of Science and Technology,Meru,Kenya [3]Centre for Biotechnol‑ogy Research and Development,Kenya Medical Research Institute,Nairobi,Kenya [4]Division of National Malaria Programme,Ministry of Health,Nairobi,Kenya [5]Department of Health,Kirinyaga County,Kirinyaga,Kenya [6]Centre for Global Health Research,Kenya Medical Research Institute,Kisumu,Kenya [7]Centers for Disease Control and Prevention,Kisumu,Kenya [8]Department of Control of Neglected Tropical Diseases,World Health Organization,Geneva,Switzerland

出　　处：《Infectious Diseases of Poverty》2021年第6期16-26,共11页贫困所致传染病（英文）

基　　金：The work was funded as a collaborative project by the WHO Pesticide Evalua‑tion Scheme,Geneva,Switzerland.

摘　　要：Background:Long-lasting insecticide nets(LLINs)are a core malaria intervention.LLINs should retain efficacy against mosquito vectors for a minimum of three years.Efficacy and durability of Olyset®Plus,a permethrin and piperonyl butoxide(PBO)treated LLIN,was evaluated versus permethrin treated Olyset®Net.In the absence of WHO guidelines of how to evaluate PBO nets,and considering the manufacturer’s product claim,Olyset®Plus was evaluated as a pyrethroid LLIN.Methods:This was a household randomized controlled trial in a malaria endemic rice cultivation zone of Kirinyaga County,Kenya between 2014 and 2017.Cone bioassays and tunnel tests were done against Anopheles gambiae Kisumu.The chemical content,fabric integrity and LLIN survivorship were monitored.Comparisons between nets were tested for signifcance using the Chi-square test.Exact binomial distribution with 95%confdence intervals(95%CI)was used for percentages.The WHO efcacy criteria used were≥95%knockdown and/or≥80%mortality rate in cone bioassays and≥80%mortality and/or≥90%blood-feeding inhibition in tunnel tests.Results:At 36 months,Olyset®Plus lost 52%permethrin and 87%PBO content;Olyset®Net lost 24%permethrin.Over 80%of Olyset®Plus and Olyset®Net passed the WHO efcacy criteria for LLINs up to 18 and 12 months,respec‑tively.At month 36,91.2%Olyset®Plus and 86.4%Olyset®Net survived,while 72%and 63%developed at least one hole.The proportionate Hole Index(pHI)values representing nets in good,serviceable and torn condition were 49.6%,27.1%and 23.2%,respectively for Olyset®Plus,and 44.9%,32.8%and 22.2%,respectively for Olyset®Net but were not signifcantly diferent.Conclusions:Olyset®Plus retained efcacy above or close to the WHO efcacy criteria for about 2 years than Olyset®Net(1–1.5 years).Both nets did not meet the 3-year WHO efcacy criteria,and showed little attrition,comparable physical durability and survivorship,with 50%of Olyset®Plus having good and serviceable condition after 3 years.Better community education on appropriate u

关 键 词：Anopheles gambiae Bioefficacy DURABILITY Kenya Long-lasting insecticidal net Olyset®Net Olyset®Plus PERMETHRIN Piperonyl butoxide 

分 类 号：R184.3[医药卫生—流行病学]