芒硝加冰片外敷治疗药物性静脉炎临床疗效和安全性的Meta分析  

Meta-analysis of clinical curative effects and safety of mirabilite and borneol for external application treatment of drug-induced phlebitis

作　　者：刘华[1] 郝海英 朱军[1] 李青荷[2] Liu Hua;Hao Haiying;Zhu Jun;Li Qinghe(Department of Intervention,Yancheng Third People's Hospital,Yancheng 224001,China;Department of Nursing,Yancheng Third People's Hospital,Yancheng 224001,China)

机构地区：[1]盐城市第三人民医院介入科,盐城224001 [2]盐城市第三人民医院护理部,盐城224001

出　　处：《中华现代护理杂志》2022年第18期2463-2468,共6页Chinese Journal of Modern Nursing

摘　　要：目的探讨芒硝加冰片外敷治疗药物性静脉炎的临床疗效和安全性。方法计算机检索中国知网、万方、维普、Pubmed、Cochrane Library、Embase等中英文数据库关于芒硝加冰片外敷治疗药物性静脉炎的相关文献,检索时限为建库至2021年10月23日。采用STATA 15.0软件对数据进行统计分析。结果共纳入9项研究,共计767例患者(治疗组患者384例,对照组患者383例)。Meta分析结果显示,芒硝加冰片治疗静脉炎的治愈率(RR=1.84,95%CI:1.40~2.42,P<0.05)、总有效率(RR=1.12,95%CI:1.02~1.24,P<0.05)、疼痛评分(SMD=3.34,95%CI:-5.20~-1.48,P<0.01)均优于对照组。结论芒硝加冰片外敷治疗较硫酸镁等其他外敷治疗制剂更适合临床治疗药物性静脉炎,在临床性能(治愈率和总有效率)及安全性(不良事件)方面均显示出优势。但由于某些指标样本量较少,所得到的量化结果应谨慎应用于临床实践,且需要进一步研究支撑此项结论。Objective To explore the clinical curative effects and safety of mirabilite and borneol for external application treatment of drug-induced phlebitis.Methods Literatures related to the treatment of drug-induced phlebitis by external application of mirabilite and borneol were searched by computer from CNKI,Wanfang,VIP,Pubmed,Cochrane Library,Embase and other Chinese and English databases.The retrieval period was from the establishment of the databases to October 23,2021.STATA 15.0 software was used for statistical analysis of data.Results A total of studies with 767 patients(384 in the treatment group and 383 in the control group)were included.Meta-analysis results showed that the cure rate of mirabilite and borneol in the treatment of phlebitis(RR=1.84,95%CI:1.40-2.42,P<0.05),the total effective rate(RR=1.12,95%CI:1.02-1.24,P<0.05)and pain score(SMD=3.34,95%CI:-5.20--1.48,P<0.01)were better than those in the control group.Conclusions External application of mirabilite and borneol is more suitable for the clinical treatment of drug-induced phlebitis than magnesium sulfate and other external treatment preparations,showing advantages in clinical performance(cure rate and total effective rate)and safety(adverse events).However,due to the small sample size of some indicators,the quantitative results obtained should be carefully applied to clinical practice and further research is needed to support this conclusion.

关 键 词：静脉炎 芒硝加冰片外敷 META分析 

分 类 号：R543.6[医药卫生—心血管疾病]