HFRT和CFRT模式对乳腺癌患者外周血淋巴细胞的影响  

Effect of HFRT and CFRT on peripheral blood lymphocytes in patients with breast cancer

作　　者：刘逸晗 殷海涛 周云 周冲 任洪荣 LIU Yihan;YIN Haitao;ZHOU Yun;ZHOU Chong;REN Hongrong(Graduate School of Xuzhou Medical University,Xuzhou 221000 China;Department of Radiotherapy,Xuzhou Clinical College of Xuzhou Medical University,Xuzhou 221000 China)

机构地区：[1]徐州医科大学研究生院,江苏徐州221000 [2]徐州医科大学徐州临床学院放疗科,江苏徐州221000

出　　处：《中国辐射卫生》2022年第3期279-283,295,共6页Chinese Journal of Radiological Health

摘　　要：目的探讨不同放疗分割模式即大分割放疗(hypofractionated radiotherapy,HFRT)和常规分割放疗(conven-tional fractionation radiotherapy,CFRT)对乳腺癌患者外周血淋巴细胞的影响。方法回顾性分析2019年11月至2021年8月在徐州市中心医院接受保乳术后放射治疗的40例早期乳腺癌患者。随机分为观察组(HFRT,n=20)与对照组(CFRT,n=20),比较2组患者放疗前及放疗中的外周血淋巴细胞计数(peripheral lymphocyte count,PLC)变化。结果大分割组和常规分割组患者的基线PLC无统计学差异(1.53±0.54 vs 1.64±0.56;P>0.05)。2组的PLC在放疗过程中稳定下降,大分割组淋巴细胞减少发生率低于常规分割组(32.5%vs 50.0%),但差异无统计学意义(P>0.05);大分割组的最低点PLC高于常规分割组(0.91±0.28 vs 0.55±0.22;P<0.001)。大分割组治疗期间的最低PLC与基线阶段的比值明显高于常规分割组(0.64±0.24 vs 0.38±0.21,P<0.05)。结论与常规分割放疗方案相比,乳腺癌患者接受大分割放疗发生放射诱导淋巴细胞减少的风险更低。Objective To investigate the effect of different fractionated radiotherapy of hypofractionated radiotherapy(HFRT)and conventional fractionated radiotherapy(CFRT)on peripheral blood lymphocytes in patients with breast cancer.Methods This retrospective analysis enrolled 40 patients with early breast cancer who underwent radiotherapy post breast conserving surgery in Xuzhou Central Hospital from November 2019 to August 2021.The patients were randomly divided into the observation group(HFRT,n=20)and the control group(CFRT,n=20).Changes in peripheral blood lymphocyte count(PLC)before and during radiotherapy were compared between the two groups.Results The baseline PLC was com-parable between the observation group and the control group(1.53±0.54 vs 1.64±0.56,P>0.05).In both groups,the PLC declined steadily during radiotherapy,and the incidence of lymphopenia in the observation group was lower than that in the control group(32.5%vs 50.0%,P>0.05);the PLC nadir was higher in the observation group than in the control group(0.91±0.28 vs 0.55±0.22,P<0.001).The ratio of the PLC nadir during treatment to baseline was significantly higher in the obser-vation group than in the control group(0.64±0.24 vs 0.38±0.21,P<0.05).Conclusion Patients with breast cancer re-ceiving HFRT show a lower risk of radiation-induced lymphopenia versus those receiving CFRT.

关 键 词：乳腺癌 放射治疗 外周淋巴细胞 大分割放疗 

分 类 号：Q691[生物学—生物物理学]