间充质干细胞源性外泌体在肺动脉高压治疗中的应用  

Application of MSCs-derived exosome in the treatment of pulmonary arterial hypertension

作　　者：陈垚鑫 邓芝花 钱进先[1] Chen Yao-xin;Deng Zhi-hua;Qian Jin-xian(Department of Respiratory and Critical Care Medicine,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School of Nanjing Medical University,Suzhou 215000,China)

机构地区：[1]南京医科大学附属苏州市立医院北区呼吸与危重症医学科,江苏苏州215000

出　　处：《中国急救医学》2022年第7期635-638,共4页Chinese Journal of Critical Care Medicine

基　　金：苏州市姑苏青年拔尖人才项目(GSWS2019061)。

摘　　要：肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的、发展性疾病,病理变化以炎症激活、肺血管重塑及血管闭塞为主,临床表现为肺动脉压力的进行性升高、右心室肥厚,甚至右心衰竭,目前的临床治疗尚缺乏改善PAH的有效治疗方法。间充质干细胞(mesenchymal stem cell,MSCs)具有多谱系分化、抗炎、修复组织等多种特征,其通过旁分泌方式分泌的外泌体具有其相似的生物功能,在PAH治疗方面发挥了重要的作用。MSCs来源的外泌体通过抑制肺动脉平滑肌细胞(pulmonary artery smooth muscle cell,PAMSC)增殖、肺动脉内皮细胞(pulmonary artory endothelial cell,PAEC)凋亡和迁移,以及调节炎症及代谢水平,改善肺血管重塑,降低肺动脉压力。本文主要介绍MSCs及其分泌的外泌体在PAH治疗方面相关机制的研究。Pulmonary arterial hypertension(PAH)is a kind of serious progressive disease.The pathological changes mainly include inflammatory activation,pulmonary vascular remodeling and vascular occlusion,leading to the progressive increase of pulmonary pressure,right ventricular hypertrophy and even right heart failure.Current clinical treatment lacks an effective method to improve PAH.Mesenchymal stem cells(MSCs)have the potential of multilineage differentiation,anti-inflammatory effect,tissue repair,and other characteristics.Exosomes derived from MSCs by paracrine manner have the similar biological functions to MSCs,and play an important role in the treatment of PAH.MSCs-derived exosomes can improve pulmonary vascular remodeling and reduce pulmonary artery pressure by inhibiting the proliferation of pulmonary artery smooth muscle cells(PAMSC),apoptosis and migration of pulmonary artery endothelial cells(PAEC),regulating the inflammation and metabolic levels.This article mainly introduces the related mechanisms of MSCs and MSCs-derived exosomes in the treatment of PAH.

关 键 词：肺动脉高压(PAH) 肺血管重塑 间充质干细胞(MSCs) 外泌体(exosome) 肺动脉平滑肌细胞(PAMSC) 肺动脉内皮细胞(PAEC) 

分 类 号：R544.1[医药卫生—心血管疾病]