流苏石斛乙醇提取物的化学成分研究  

Chemical constituents from the ethanol extracts of Dendrobium fimbriatum Hook

作　　者：刘莎莎[1] 李红锐 孙静贤[1] 王瑞生 邵金良[2] 刘宏程[2] 黄相中[1] 李艳红[1] LIU Sha-sha;LI Hong-rui;SUN Jing-xian;WANG Rui-sheng;SHAO Jin-liang;LIU Hong-cheng;HUANG Xiang-zhong;LI Yan-hong(Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission and Ministry of Education,Yunnan Minzu University,Kunming 650504,China;Institute of Quality Standard and Testing Technology,Yunnan Academy of Agricultural Sciences,Kunming 650205,China)

机构地区：[1]云南民族大学民族药资源化学国家民委-教育部重点实验室,云南昆明650504 [2]云南省农业科学院质量标准与检测技术研究所,云南昆明650205

出　　处：《云南民族大学学报（自然科学版）》2022年第4期375-380,共6页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：国家自然科学基金(81960783);云南省自然科学基金(202101AT070111);云南省高校传统彝药药效物质基础研究科技创新团队项目;民族药资源化学国家民委-教育部重点实验室(云南民族大学)开放基金(2017KF01).

摘　　要：研究流苏石斛Dendrobium fimbriatum Hook.的化学成分及其生物活性.利用硅胶、葡聚糖凝胶层析及C_(18)色谱柱等方法从流苏石斛95%乙醇提取物中分离得到11个化合物,根据其理化性质及核磁数据分析,分别鉴定为moscatin(1)、batatasinⅢ(2)、石斛酚(3)、moscatilin(4)、柚皮素(5)、松柏醛(6)、scoparone(7)、对羟基苯甲醛(8)、薯蓣皂素(9)、7-酮基-β-谷甾醇(10)和熊果酸(11).化合物5~11均为首次从该植物中分离得到.通过RAW264.7模型和α-葡萄糖苷酶抑制模型对所有化合物进行体外活性筛选,部分化合物表现一定的体外抗炎和α-葡萄糖苷酶抑制活性.Study on the chemical constituents and bioactivities of Dendrobium fimbriatum Hookwas launched.Eleven compounds were separated from 95%ethanol extract of D.fimbriatum by using silica gel,Sephadex LH-20 and C_(18) chromatographic techniques.These compounds were identified as moscatin(1),batatasinⅢ(2),gigantol(3),moscatilin(4),naringenin(5),coniferaldehyde(6),scoparone(7),p-hydroxybenzaldehyde(8),diosgenin(9),7-keto-β-sitosterol(10),and ursolic acid(11)by analyzing physicochemical property and NMR spectral data.Compounds 5—11 were isolated from this plant for the first time.The bioactivities of all compounds were evaluated by the RAW264.7 andα-glucosidase inhibition models.Some of the compounds showed moderate anti-inflammatory and anti-α-glucosidase activities in vitro.

关 键 词：流苏石斛 化学成分 抗炎活性 α-葡萄糖苷酶抑制活性 

分 类 号：R284.1[医药卫生—中药学]