Constructive strategies for drug delivery systems in antivirus disease therapy by biosafety materials  

作　　者：Li Wang Zhaoshuo Wang Lingzhi Cao Kun Ge 

机构地区：[1]Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education,Key Laboratory of Chemical Biology of Hebei Province,College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China

出　　处：《Biosafety and Health》2022年第3期161-170,共10页生物安全与健康（英文）

基　　金：supported by the National Key Research&Development Program of China(No.2021YFA1201000);the Government Guided Local Science and Technology Development Fund Projects of Hebei Province(No.216Z2403G);Natural Science Foundation of Hebei Province(No.B2019201449,H2019201466);the Priority Strategy Project of the Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education(ts2020003);the Hebei Province“Three Three Three Talents Program”(A202003001).

摘　　要：Due to the coronavirus disease 2019(COVID‐19)pandemic,the development of antiviral drugs has attracted increasing attention.Clinical antiviral drugs show weak solubility,low bioavailability,adverse side effects,or only limited targets.With the advancement of nanotechnology and material science,biosafety nanomaterials have been constructed for drug delivery systems of antiviral disease therapy,such as liposomes,polymers,gold nanoparticles,and graphene.These nanodrug systems can either deliver synthesized antiviral drugs siRNA/miRNA and small molecular compounds,deliver bioactive large molecular drug proteins and mRNA,or show antiviral activity by themselves.Nanodelivery systems could effectively enhance the efficiency of antiviral drugs by increasing drug loading and host cell uptake with a small size and high specific surface area.This review focused on the biosafety nanomaterials used for antiviral therapy and discussed the options for the design of antiviral drugs in the future.

关 键 词：Antivirus therapy Nanodelivery systems Compound drugs Biologically active molecule drugs 

分 类 号：R943[医药卫生—药剂学]