硝酸咪康唑与制霉菌素治疗念珠菌性阴道炎的临床研究  

Clinical Study of Miconazole Nitrate and Nystatin in Treatment of Candidal Vaginitis

作　　者：胡艳 Hu Yan(Obstetrics Department of Jingmen City Women and Children's Health Hospital,Jingmen 448000,Hubei Province,China)

机构地区：[1]湖北省荆门市妇幼保健院产科,湖北荆门448000

出　　处：《中国社区医师》2022年第17期37-39,共3页Chinese Community Doctors

摘　　要：目的:分析妊娠合并念珠菌性阴道炎的患者采取硝酸咪康唑与制霉菌素临床效果。方法:随机选取荆门市妇幼保健收治的200例确诊的妊娠合并念珠菌性阴道炎的患者作为研究对象,并依据治疗用药将其分为三组,硝酸咪康唑组70例、制霉菌素组70例、对照组60例。三组患者都使用2%的碳酸氢钠溶液清洁外阴及阴道,日常洗护干预,硝酸咪康唑组实施硝酸咪康唑的阴道后穹隆位置干预,持续干预时间为7 d;制霉菌素组则采取1.0×10^(5) U的制霉菌素置入阴道后穹隆,连续1周。观察分析三组患者的一般情况、临床效果、不良反应、复发率及娩出新生儿的皮肤携菌率。结果:采用不同治疗方案后,硝酸咪康唑组、制霉菌素组及对照组患者的临床疗效并无明显区别,差异无统计学意义(P>0.05)。硝酸咪康唑组的不良反应发生率与制霉菌素组及对照组患者发生不良反应的情况进行比较,差异无统计学意义(P>0.05)。三组患者的复发率比较,差异无统计学意义(P>0.05)。三组经产道分娩与剖宫分娩的新生儿携菌情况比较,差异无统计学意义(P>0.05)。结论:此二种药物在治疗妊娠合并念珠菌性阴道炎中,用药的安全性、有效性与疾病的复发率都没有显著差异,治疗效果明显,在临床中有积极意义,值得推广。Objective:To take the clinical intervention of miconazole nitrate and nystatin in patients with pregnancy complicated with candida vaginitis,compare the clinical effect after the intervention,and make an in-depth analysis to provide help for formulating a more reasonable treatment plan.Methods:A total of 200 patients with pregnancy complicated with candida vaginitis who were admitted to Jingmen City Women and Children's Health Hospital were randomly selected as the study subjects,and they were divided into three groups according to the medications:miconazole nitrate group(70 cases),nystatin group(70 cases)and control group(60 cases).All patients in three groups were treated with 2%sodium bicarbonate solution to clean the vulva and vagina as daily washing and nursing intervention.The miconazole nitrate group was given miconazole nitrate intervention in the posterior fornix of the vagina,and the intervention time was 7 days;the nystatin group was given 1.0×10^(5) U of nystatin placed into the posterior fornix of the vagina for continuous 1 week.The general conditions,clinical effects,adverse reactions,recurrence rate and skin bacteria carrying rate of delivered neonates in the three groups were observed and analyzed.Results:After different treatment regimens,the clinical efficacy of miconazole nitrate group,nystatin group and control group was not significantly different(P>0.05).The incidence of adverse reactions in the miconazole nitrate group was compared with that in the nystatin group and the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the recurrence rate among the three groups(P>0.05).There was no statistically significant difference in the bacteria-carrying status of neonates delivered via birth canal and cesarean section among the three groups(P>0.05).Conclusion:In the treatment of pregnancy complicated with candida vaginitis,there is no significant difference in the safety and effectiveness of the two drugs and the recurrence rate of the dis

关 键 词：硝酸咪康唑 制霉菌素 妊娠 念珠菌性阴道炎 

分 类 号：R473.71[医药卫生—护理学]