温阳通脉方治疗寒凝血脉型颈动脉粥样硬化斑块临床观察  

Efficacy observation of Wenyang Tongmai formula on carotid atherosclerotic plaque with syndrome of cold-coagulation in blood vessel

作　　者：蒋孝军 张波 JIANG Xiao-jun;ZHANG Bo(Anhui University of Traditional Chinese Medicine,Hefei 230038,China;不详)

机构地区：[1]安徽中医药大学,合肥230038 [2]安徽中医药大学第一附属医院

出　　处：《山西中医》2022年第7期12-14,共3页Shanxi Journal of Traditional Chinese Medicine

摘　　要：目的:观察温阳通脉方联合阿托伐他汀钙片治疗寒凝血脉型颈动脉粥样硬化斑块(CAS)的临床疗效。方法:选取确诊的寒凝血脉型CAS住院患者60例,随机数字表法分为两组各30例,对照组脱落2例,治疗组脱落3例。对照组予阿托伐他汀钙片治疗,治疗组在对照组基础上加服温阳通脉方,两组均连续治疗9个月后比较两组中医证候积分、血脂(TG、TC、LDL-C、HDL-C)水平、Crouse积分、颈动脉内中膜厚度(IMT)和CAS的面积变化;对比两组临床疗效及不良反应情况。结果:治疗后,两组患者的中医证候积分、Crouse积分、IMT、CAS面积均有所减低,血脂水平改善,治疗组较对照组改善更明显,差异均有统计学意义(P﹤0.05)。结论:温阳通脉方治疗寒凝血脉型CAS有较好的临床疗效。Objective:To observe the clinical efficacy of Wenyang Tongmai formula and Atorvastatin calcium tablets on carotid atherosclerotic plaque(CAS)with syndrome of cold-coagulation in blood vessel.Methods:60 cases of selected inpatients,who were diagnosed as CAS of cold-coagulation in blood vessel type,were randomly divided into control group(28 cases,2 cases lost)and treatment group(27 cases,3 cases lost)by random number table method.The control group was treated with Atorvastatin calcium tablets,while the treatment group was treated plus with oral Wenyang Tongmai formula on the basis of control group.After both groups were treated continuously for 9 months,the changes of TCM symptom score,level of blood lipid(TG,TC,LDL-C,HDL-C),Crouse score,carotid intima-media thickness(IMT)and CAS area were compared between two groups,and the clinical efficacy and adverse reactions were compared between two groups.Results:After treatment,TCM syndrome score,Crouse score,IMT,and CAS area of patients in both groups were decreased;the level of blood lipid was improved,and the improvement of treatment group was more significant than that of control group,and the difference was statistically significant(P﹤0.05).Conclusion:Wenyang Tongmai formula has a better clinical efficacy on carotid atherosclerotic plaque(CAS)with syndrome of cold-coagulation in blood vessel.

关 键 词：颈动脉粥样硬化斑块 寒凝血脉 温阳通脉方 中医药疗法 

分 类 号：R543.4[医药卫生—心血管疾病]