维生素D/维生素D受体、自噬与感染  

Vitamin D/vitamin D receptor,autophagy,and infection

作　　者：侯宇[1] 李景辉[1] 邓超[1] HOU Yu;LI Jinghui;DENG Chao(Department of Critical Care Medicine,Affiliated Haikou Hospital of Xiangya School of Medicine,Central South University,Haikou 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院重症医学科,海口570208

出　　处：《中南大学学报（医学版）》2022年第6期780-785,共6页Journal of Central South University ：Medical Science

基　　金：海南省自然科学基金(819MS139)。

摘　　要：维生素D在钙磷代谢中起重要作用,同时具有调节机体免疫功能、心血管功能及角质形成细胞增殖和分化的能力。维生素D的大部分功能是通过与维生素D受体(vitamin receptor,VDR)结合后实现的,VDR信号通路与其他细胞内信号通路相互作用,从而调节骨代谢、炎症反应、免疫反应、细胞周期进程和凋亡。细胞自噬在酵母、植物和哺乳动物中是一种基本的应激反应,对维持细胞和器官的最佳功能状态起至关重要的作用。维生素D/VDR通过诱导和调节自噬发挥抗感染的作用。Vitamin D plays an important role in mineral and bone homeostasis,immune responses,cardiovascular function and keratinocyte proliferation and differentiation.Vitamin D performs most of its functions by binding to vitamin D receptors(VDR),which interact with other intracellular signaling pathways to regulate bone metabolism,inflammation,immunity,cell cycle progression and apoptosis.Autophagy is a basic stress response in yeast,plants and mammals,and plays a critical role in maintaining optimal functional states at the level of cells and organs.Vitamin D/VDR plays an anti-infection role via inducing and regulating autophagy.

关 键 词：维生素D 维生素D受体 自噬 感染 

分 类 号：R591.44[医药卫生—内科学]