益生菌治疗过敏性疾病机制及应用的研究进展  

Progress on the mechanism and application of probiotic therapy for allergic diseases

作　　者：刘夏 侯彬彬[2] LIU Xia;HOU Binbin(Dalian Medical University,Dalian 116044,China)

机构地区：[1]大连医科大学,辽宁大连116044 [2]大连医科大学附属第二医院,辽宁大连116044

出　　处：《实用医学杂志》2022年第11期1434-1438,共5页The Journal of Practical Medicine

基　　金：辽宁省科技厅自然科学基金项目(编号:LZ2020066)。

摘　　要：过敏性疾病的传统治疗方法,主要是口服抗过敏药物,但长期使用会存在副作用,尤其是对婴幼儿、孕妇以及老年人。有研究发现,过敏性疾病患者的肠道菌群,其分布、丰度存在独有特征,如双歧-拟杆菌倒置分布现象。还有研究发现,益生菌可通过调节免疫反应,缓解过敏症状,对于过敏性疾病的预防和辅助治疗均有效,可大大降低传统抗过敏药的副作用,并且价格相对低廉,副作用少,易于广大民众接受。故对于益生菌抗过敏菌株的研究以及相关制剂的研发已成为目前的研究热点。目前,益生菌治疗过敏性疾病的具体机制尚不明确。本文综述了益生菌抗过敏机制的研究进展,并总结了益生菌的临床应用。最后,对益生菌防治过敏性疾病的前景进行了展望。Traditional treatment for allergic diseases is primarily oral anti-allergy drugs,but long-term use has side effects,particularly in infants,pregnant women,and the elderly. According to research,the distribution and abundance of intestinal flora in patients with allergic diseases exhibit distinct characteristics,such as the bifoldbacteroide inverted distribution phenomenon. Probiotics have been shown in studies to relieve allergic symptoms by regulating immune reactions,making them useful for the prevention and adjuvant treatment of allergic diseases.Probiotics significantly reduce the side effects of traditional anti-allergy drugs while being relatively inexpensive and having fewer side effects.Therefore,the general public readily accepts probiotics. As a result,probiotic antiallergic strain research and the development of related preparations have received a lot of attention.However,the mechanism by which probiotics treat allergic diseases is still unknown. Here,we review the progress of research into probiotics′ anti-allergy mechanism,summarize clinical applications of probiotics,and finally forecast the future of probiotics for the prevention and treatment of allergic diseases.

关 键 词：益生菌 过敏性疾病 免疫 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]