尿源干细胞及其细胞外囊泡在再生医学中的研究进展  

Research progressof urine-derived stem cells and their extracellular vesicles in regenerative medicine

作　　者：徐依赟 邱雨 吴氢凯[1] XU Yiyun;QIU Yu;WU Qingkai(Department of Obstetrics and Gynecology,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院妇产科,上海200233

出　　处：《同济大学学报（医学版）》2022年第3期442-447,共6页Journal of Tongji University(Medical Science)

基　　金：国家自然科学基金(82071631,81771523)。

摘　　要：尿源干细胞(urine-derived stem cells, USCs)是一种具有良好扩增能力、多系分化潜能、旁分泌功能的新型干细胞。因其可以从尿液样本中分离,具有收样方便、取材无创、伦理问题少等优势,越来越引起人们的关注。目前,尿源干细胞作为一种理想的干细胞来源,有望广泛应用于组织工程和再生医学领域。细胞外囊泡(extracellular vesicles, EVs)是由干细胞通过旁分泌途径产生的类似干细胞功能的囊泡结构。多项研究证明EVs在细胞间通信、免疫调节、炎症反应、细胞增殖与凋亡等方面发挥重要生物学作用。本文就尿源干细胞及其细胞外囊泡在再生医学中的最新研究进展和应用前景进行综述。Urine-derived stem cells(USCs) are a type of stem cells with good expansion ability, multi-differentiation potential and paracrine function. USCs have attracted increasing attention because they can be easily and non-invasively obtained from urine samples with less ethics restrictions. USCs, an ideal source of stem cells, are expected to be widely used in tissue engineering and regenerative medicine. Extracellular vesicles(EVs) are secreted by stem cells through paracrine pathways and have similar functions as stem cells. Many studies have shown that EVs play an important role in intercellular communication, immune regulation, inflammatory response, proliferation, apoptosis and so on. In this article, we intend to review the latest research progress and application prospect of USCs and USCs-EVs in regenerative medicine.

关 键 词：尿源干细胞 细胞外囊泡 再生医学 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]