化痰补气活血方对2型糖尿病合并脑梗死患者炎性因子、凝血功能的影响及疗效分析  

Effect of Huatanbuqihuoxue recipe on patients with type 2 diabetes complicated with cerebral infarction and influence on inflammatory factors and coagulation function

作　　者：谭淑静 么娇子 黄蕊 张凤莲[2] 李伟[2] Tan Shujing;Yao Jiaozi;Huang Rui;Zhang Fenglian;Li Wei(Department of Traditional Chinese Medicine,Tangshan People's Hospital,Hebei Province,Tangshan 063001,China;不详)

机构地区：[1]河北省唐山市人民医院中医科,063001 [2]河北省唐山市人民医院神经内科,063001

出　　处：《疑难病杂志》2022年第7期721-725,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：河北省中医药科研计划项目(2020415)。

摘　　要：目的分析化痰补气活血方对2型糖尿病并发急性脑梗死患者炎性因子和凝血功能的影响及疗效。方法收集2016年1月—2019年8月唐山市人民医院收治的2型糖尿病并发急性脑梗死患者85例,按随机数字表法分为对照组(n=42)和观察组(n=43)。对照组患者给予临床西药常规基础方案治疗,观察组患者在此基础上联用化痰补气活血中药治疗,2组均治疗4周。观察2组患者血清炎性因子C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)和凝血指标凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体(D-D)水平改变,检测改良Barthel指数(BI)评分及NIHSS评分变化情况,并观察比较2组临床疗效。结果治疗4周后,对照组临床总有效率为69.04%,观察组临床总有效率为88.37%,观察组显著高于对照组,差异有统计学意义(χ^(2)=4.753,P<0.05)。2组治疗后的血清炎性因子水平均较治疗前显著下降(P<0.05或P<0.01),且治疗后观察组CRP、TNF-α、IL-6和IL-8水平低于对照组(6.257/<0.001、5.233/<0.001、5.324/0.005、6.251<0.001);2组治疗后的凝血功能指标PT和APTT均缩短,D-二聚体水平均降低(P<0.05),且治疗后观察组PT和APTT缩短及D-二聚体降低的水平大于对照组(3.568/<0.001、4.265/<0.001、3.303/0.008);治疗后2组BI评分增加,NIHSS评分下降,且观察组改善更为明显(4.080/<0.001、3.965/>0.001)。结论化痰补气活血中药治疗能够减轻2型糖尿病并发急性脑卒中患者的炎性微环境,改善凝血功能,促进神经功能恢复,值得在临床推广使用。Objective To analyze the effect of Huatanbuqihuoxue recipe on inflammatory factors and coagulation function in patients with type 2 diabetes complicated with acute stroke.Methods Eighty-five patients with type 2 diabetes complicated with acute stroke treated in Tangshan people's Hospital from January 2016 to August 2019 were collected and randomly divided into control group(n=42)and observation group(n=43).The patients in the control group were treated with routine basic scheme of clinical western medicine,and the patients in the observation group were treated with traditional Chinese medicine for resolving phlegm,invigorating qi and activating blood circulation on this basis.Both the control group and the observation group were treated for 4 weeks.Observe the serum inflammatory factor C-reactive protein(CRP)and tumor necrosis factor in the two groups-α(TNF-α),The levels of interleukin-6(IL-6),interleukin-8(IL-8)and blood coagulation environmental indicators prothrombin time(PT),activated partial thromboplastin time(APTT),D-Dimer(D-D)were changed.The changes of modified Barthel Index(BI)score and NIHSS score were tested,and the curative effects of the two groups were observed.Results After 4 weeks of treatment,the total clinical effective rate was 69.04%in the control group and 88.37%in the observation group,which was significantly higher than that in the control group(χ^(2)=4.753,P<0.05).The levels of serum inflammatory factors in both groups after treatment were significantly lower than those before treatment(P<0.05 or P<0.01),and CRP and TNF-αin the observation group after treatment.The levels of IL-6 and IL-8 were lower than those in the control group(6.257/<0.001,5.233/<0.001,5.324/0.005,6.251<0.001);After treatment,the coagulation function indexes Pt and APTT of the two groups were shortened,and the level of D-dimer was reduced(P<0.05),and the shortened Pt and APTT and the level of D-dimer in the observation group were higher than those in the control group(3.568/<0.001,4.265/<0.001,3.303/0.008);After t

关 键 词：2型糖尿病 脑梗死 化痰补气活血方 炎性因子 凝血功能 神经功能 

分 类 号：R563.9[医药卫生—呼吸系统]