雌激素调节自噬的细胞保护作用研究进展  

Research progress of estrogen-regulated autophagic cytoprotective effects

作　　者：孙琦 张红(综述) 赵自刚(审校)[1] Sun Qi;Zhang Hong;Zhao Zigang(Institute of Microcirculation, Hebei North University, Hebei Province,Zhangjiakou 075000 ,China)

机构地区：[1]河北北方学院微循环研究所,张家口075000

出　　处：《疑难病杂志》2022年第7期763-767,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金面上项目(81670446、81770492)。

摘　　要：雌激素通过雌激素受体发挥多种药理学作用。细胞自噬作为真核细胞普遍存在的细胞本体降解系统,参与多种疾病的发生发展。文章以雌激素对自噬通量发挥双向调节作用为切入点,综述雌激素抑制细胞自噬发挥的神经、心肌保护作用,以及诱导自噬发挥的神经、心肌、肝细胞与骨保护作用,以期针对细胞自噬扩展对雌激素药理学作用的理解。Estrogen exerts a variety of pharmacological effects through the estrogen receptor.As a ubiquitous cell body degradation system in eukaryotic cells,autophagy is involved in the occurrence and development of various diseases.This article takes the bidirectional regulation effect of estrogen on autophagy flux as an entry point,and reviews the neural and cardioprotective effects of estrogen inhibiting autophagy,as well as the neural,myocardial,hepatocyte and bone protective effects of estrogen-induced autophagy.Expanding understanding of estrogen pharmacology towards autophagy.

关 键 词：雌激素 细胞自噬 雌激素受体 作用机制 

分 类 号：R255[医药卫生—中医内科学] R458.7[医药卫生—中医学]