丹皮酚混悬剂的制备  

Preparation of paeonol suspension

作　　者：李岩 陈梦菲 张赫彬 李金涛 刘冰雨 苏瑞 LI Yan;CHEN Mengfei;ZHANG Hebin;LI Jintao;LIU Bingyu;SU Rui(Heze Medical College,Heze,274000,China)

机构地区：[1]菏泽医学专科学校,山东菏泽274000

出　　处：《江西化工》2022年第3期78-80,共3页Jiangxi Chemical Industry

基　　金：山东省医药卫生科技发展计划项目(2018WS494);山东省中医药科技发展计划项目(2019-0320)。

摘　　要：目的:制备优良的丹皮酚混悬剂,为科学研究提供有效的实验材料。方法:通过研磨和涡旋两种分散法制备丹皮酚混悬剂,以沉降容积比和重新分散为质量评价指标。结果:利用阿拉伯胶制备丹皮酚混悬剂,其3h后的沉降容积比为0.98,3次振摇后可以使药物重新分散。结论:以阿拉伯胶作为助悬剂通过研磨法制备的丹皮酚混悬剂,其外观细腻,分散微粒较细小,沉淀容积最大,稳定性最好。Objective:To produce paeonol suspension and provide effective experimental materials for scientific research.Methods:To produce paeonol suspension by grinding and vortex dispersion;to take the settlement volume ratio and re-dispersion of paeonol suspension as the quality evaluation indicators for the stability of paeonol suspension.Results:The settlement volume ratio of paeonol suspension produced by grinding with Arabic gum is 0.98,and the drug is re-dispersed after 3 times of shaking.Conclusion:Paeonol suspension produced by grinding method with Arabic gum as suspension agent has fine appearance and smaller discrete particles with maximum precipitation capacity and the best stability.

关 键 词：丹皮酚 助悬剂 稳定性 

分 类 号：TQ460.1[化学工程—制药化工]