HIV-1感染者病毒学指标与血浆中白细胞介素表达水平的相关性研究  

Correlation between virological indexes and plasma interleukin levels in HIV-1 infected patients

作　　者：毕铭辕 李建辉 康文(指导) 孙永涛(指导)[1] BI Mingyuan;LI Jianhui;KANG Wen;SUN Yongtao(Department of Infectious Diseases,the Second Affiliated Hospital of Air Force Military Medical University,Xi'an 710038,China)

机构地区：[1]中国人民解放军空医军医大学第二附属医院传染病科,西安710038

出　　处：《中国免疫学杂志》2022年第10期1233-1236,1244,共5页Chinese Journal of Immunology

基　　金：“十三五”国家科技重大专项项目(2017ZX10202101-004-005,2017ZX10202101-003-007,2017ZX10202102-002-001)。

摘　　要：目的:探究未治疗的人类免疫缺陷病毒(HIV-1)感染者不同HIV-1 RNA或HIV-1 DNA水平组患者血浆IL-1β、IL-6、IL-8、IL-10、IL-16和IL-18表达差异及其与HIV-1 RNA或HIV-1 DNA的相关性。方法:选取未治疗HIV-1感染者75例,检测其HIV-1 RNA、HIV-1 DNA水平、CD4+T细胞、CD8+T细胞计数及血浆IL-1β、IL-6、IL-8、IL-10、IL-16和IL-18表达。结果:不同组患者血浆IL-1β、IL-6、IL-10、IL-16和IL-18表达存在明显差异,且与HIV-1 RNA、HIV-1 DNA水平相关(P<0.05)。结论:高病毒载量的未治疗HIV-1感染者血浆IL-10、IL-18表达较高,IL-1β、IL-6和IL-16表达较低,且均与病毒载量相关;高HIV-1 DNA水平的未治疗HIV-1感染者血浆IL-10、IL-18表达较高,IL-6、IL-16表达较低,且均与HIV-1 DNA水平呈正相关,说明也可能与病毒储存库相关。Objective:To investigate difference of IL-1β,IL-6,IL-8,IL-10,IL-16 and IL-18 expressions in plasma of patients and their correlation with HIV-1 RNA or HIV-1 DNA in untreated human immunodeficiency virus(HIV-1)infected people with different levels of HIV-1 RNA or HIV-1 DNA.Methods:HIV-1 RNA,HIV-1 DNA levels,CD4+T cells,CD8+T cells counts and plasma expressions of IL-1β,IL-6,IL-8,IL-10,IL-16 and IL-18 were detected in 75 untreated HIV-1 infected patients.Results:Expressions of IL-1β,IL-6,IL-10,IL-16 and IL-18 in plasma were significantly different among different groups,and correlated with HIV-1 RNA and HIV-1 DNA levels(P<0.05).Conclusion:Expressions of IL-10 and IL-18 in plasma of untreated HIV-1 patients with high viral load were higher,while expressions of IL-1β,IL-6 and IL-16 were lower,which were correlated with viral load.Expressions of IL-10 and IL-18 in plasma of untreated HIV-1 patients with high HIV-1 DNA levels were higher,while expressions of IL-6and IL-16 were lower,and both of them were positively correlated with HIV-1 DNA level,indicating that they might also be correlated with virus repository.

关 键 词：人类免疫缺陷病毒 白细胞介素 HIV-1 RNA HIV-1 DNA 

分 类 号：R512.91[医药卫生—内科学]