绝经后骨质疏松患者骨组织中miR-124-3p、miR-328-3p、miR-338-3p的表达  

Expression of miR-124-3p,miR-328-3p and miR-338-3p in bone tissue of postmenopausal osteoporosis patients

作　　者：牟朋林 麦彩园[2] 曹燕明[3] 王斌 MOU Peng-lin;MAI Cai-yuan;CAO Yan-ming;无(Guangzhou Xinhai Hospital,Guangzhou 510080,China;Guangdong Women and Children's Hospital,Guangzhou 510010,China;The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China;The People's Hospital of Sanshui,Foshan,Foshan528100,China)

机构地区：[1]广州新海医院,广东广州510080 [2]广东省妇幼保健院,广东广州510010 [3]广州医科大学附属第二医院,广东广州510260 [4]佛山市三水区人民医院,广东佛山528100

出　　处：《吉林医学》2022年第7期1771-1774,共4页Jilin Medical Journal

基　　金：国家自然科学基金[项目编号:81574002];广东省医学科学技术研究基金[项目编号:A2020377];佛山市科技局科研立项[项目编号:2018AB000595]。

摘　　要：目的:探讨绝经后骨质疏松患者骨组织中miR-124-3p、miR-328-3p、miR-338-3p表达。方法:选取30例绝经后骨质疏松妇女(PMOP组)和30例非骨质疏松的绝经后妇女(对照组),髂前上棘穿刺取骨组织300mg,研磨、匀浆,通过RT-qPCR方法分析检测两组miR-124-3p、miR-328-3p、miR-338-3p的表达水平。结果:miR-338-3p在PMOP组骨组织中的表达水平升高;miR-124-3p、miR-328-3p在PMOP组骨组织中的表达水平降低。结论:miR-124-3p、miR-328-3p、miR-338-3p可调节成骨、破骨引起PMOP,可通过调控其表达干预PMOP的发生和治疗。Objective To investigate the expression of miR-124-3p,miR-328-3p and miR-338-3p in bone tissue of postmenopausal osteoporosis patients.Method A total of 30 postmenopausal osteoporosis women(PMOP group)and 30 non-osteoporosis postmenopausal women(control group)were selected.At the same time,300 mg of bone tissue was extracted from anterior superior iliac spine puncture.Grinded and homogenated.The expression levels ofmiR-124-3p,miR-328-3p and miR-338-3p were detected by RT-qPCR analysis in two groups.Results The expression level of miR-338-3p in bone tissue of PMOP group was increased,and the expression level of miR-124-3p and miR-328-3p in bone tissue of PMOP group was decreased.Conclusion MiR-124-3p,miR-328-3p and miR-338-3p can regulate osteogenesis and osteoclastogenesis to cause PMOP,and can intervene the occurrence and treatment of PMOP by regulating its expression.

关 键 词：绝经后骨质疏松 miR-124-3p miR-328-3p miR-338-3p 

分 类 号：R580[医药卫生—内分泌]