不同时间服用阿利沙坦酯对高血压患者血压昼夜节律的影响  

Influence of allisartan isoproxil on circadian rhythm of blood pressure at different taking time in patients with hypertension

作　　者：段勇 李慧 DUAN Yong;LI Hui(Department of Cardiovascular Medicine,The Third Hospital of Changsha,Changsha 410000,China)

机构地区：[1]长沙市第三医院心血管内科,湖南长沙410000

出　　处：《吉林医学》2022年第7期1834-1836,共3页Jilin Medical Journal

摘　　要：目的:探讨不同时间服用阿利沙坦酯对高血压患者血压昼夜节律的影响。方法:选取长沙市第三医院心血管内科门诊收治的82例1~2级高血压患者随机分为日间服药组(7∶00~9∶00)和夜间服药组(19∶00~21∶00),两组均服用阿利沙坦酯片240 mg,1次/d,疗程14 d。治疗前及治疗14 d后均行24 h动态血压监测,比较两组患者治疗前后血压水平及非杓型高血压节律情况。结果:治疗14 d后的白天平均收缩压(dMSBP)、白天平均舒张压(dMDBP)、夜间平均收缩压(nMSBP)和夜间平均舒张压(nMDBP)与治疗前相比均显著降低,差异有统计学意义(P<0.05或P<0.01);与日间服药组相比,夜间服药组治疗14 d后的nMSBP和nMDBP降低更显著,差异有统计学意义(P均<0.05)。夜间服药组14 d后非杓型高血压患者比例低于日间服药组,差异有统计学意义(P=0.033<0.05)。结论:阿利沙坦酯能有效降低1~2级高血压患者血压,夜间服药较白天服药能更显著降低夜间血压,维持正常的血压昼夜节律。Objective To investigate the effect of allisartan isoproxil on circadian rhythm of blood pressure in patients with hypertension.Method A total of 82 patientswith grade 1 to 2 hypertension,who were treated in the Cardiovascular Clinic of the Third Hospital of Changsha,were randomly and equally divided into daytime administration group(7∶00~9∶00)and nighttime administration group(19∶00~21∶00).Both group received allisartan isoproxiltablets 240mg/day during corresponding period for 14 days.All patients received before and after treatment.Before treatment and 14 days after treatment,24h ambulatory blood pressure minitoring was performed,and blood pressure levels and rhythm of non-dipping hypertension were compared in two groups before and after treatment.Results After 14 days of treatment,the mean daytime systolic blood pressure(dMSBP),the mean daytime diastolic blood pressure(dMDBP),the mean nighttime systolic blood pressure(nMSBP)and the mean nighttime diastolic blood pressure(nMDBP)were significantly decreased compared with before treatment,and the differences were statistically significant(P<0.05 or P<0.01).Compared with daytime group,nMSBP and nMDBP decreased more significantly in nighttime group after 14 days of treatment,the differences were statistically significant(P<0.05).After 14 days,the proportion of non-dipping hypertension patients in the nighttime group was lower than that in the daytime group,the difference was statistically significant(P=0.033<0.05).Conclusion Allisartan isoproxil can effectively reduce blood pressure in patients with grade 1~2 hypertension,night medication can significantly reduce blood pressure at night compared with day medication,and maintain normal circadian rhythm of blood pressure.

关 键 词：高血压 阿利沙坦酯 昼夜节律 非杓型高血压 

分 类 号：R544.1[医药卫生—心血管疾病]