HBV感染与抗平滑肌抗体相关性分析  

Correlation analysis of hepatitis B virus infection and anti-smooth muscle antibody

作　　者：马跃飞[1] 贺勤 刘灿[1] 林锦骠[1] 刘晓峰[1] 王炳龙[1] 杨滨[1] 欧启水[1] MA Yuefei;HE Qin;LIU Can;LIN Jinpiao;LIU Xiaofeng;WANG Binglong;YANG Bin;OU Qishui(Department of Clinical Laboratory,the First Affiliated Hospital,Fujian Medical University,Fujian Key Laboratory of Laboratory Medicine,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院检验科福建省检验医学重点实验室,福州350005

出　　处：《中国免疫学杂志》2022年第7期864-867,877,共5页Chinese Journal of Immunology

摘　　要：目的:探讨HBV感染者病毒活动情况、疾病进程与血清抗平滑肌抗体(ASMA)产生的相关性。方法:回顾性分析我院2014年6月至2018年6月间慢性乙型病毒性肝炎(CHB)患者肝病自身抗体检测结果。筛选51例合并ASMA阳性患者的临床资料和实验室进行数据分析,以自身抗体检测阴性的50例CHB患者作为对照。分析两组的临床表现、肝功能、乙肝病毒活动情况和疾病进程的差异。结果:抗核抗体(ANA)、ASMA、抗线粒体抗体(AMA)和抗肝肾微粒体抗体(LKM-1)在CHB受检者中阳性率分别为13.46%、5.01%、0.60%和0.07%。ASMA阳性组和自身抗体阴性组患者的年龄、性别构成、HBsAg感染年限、HBsAg、HBeAg和HBV DNA对数值,以及CHB疾病进程等差异均无统计学意义(P>0.05)。ASMA阳性组首发症状多见黄疸,部分合并肝外自身免疫性疾病表现(P<0.05)。ASMA阳性组TBIL、ALP、TBA、PT高于自身抗体阴性组,ALB低于自身抗体阴性组,差异均有统计学意义(P<0.05)。ASMA阳性组中肝炎、肝硬化和肝癌患者的ASMA滴度差异无统计学意义(P>0.05)。结论:ASMA与乙肝病毒复制活动性和疾病病程无相关性。Objective:To investigate the correlation between virus replication,disease progression and serum anti-smooth muscle antibody(ASMA)production in patients with hepatitis B virus infection.Methods:The positive rate of autoantibodies related to autoimmune liver disease in patients with chronic hepatitis B(CHB)from June 2014 to June 2018 in our hospital was analyzed retrospectively.Clinical information and laboratory data of 51 CHB patients with ASMA positive were analyzed,50 patients with CHB who had negative autoantibody detection during the period were randomly selected as autoantibody negative group.The clinical manifestations,liver function,replication of hepatitis B virus and disease progression of the two groups were compared and analyzed.Results:The positive rate of anti-nuclear antibody(ANA),ASMA,anti-mitochondrial antibody(AMA)and liver kidney microsomal type 1 antibody(LKM-1)were 13.46%,5.01%,0.60% and 0.07%,respectively.There was no significant difference in age,sex composition and HBsAg duration between the ASMA positive group and the autoantibody negative group(P>0.05).The first symptoms in the ASMA positive group were mostly jaundice with extrahepatic autoimmune disease symptom(P0.05).There was no significant difference of ASMA titer in patients with hepatitis,liver cirrhosis and liver cancer in the ASMA positive group(P>0.05).Conclusion:The production of ASMA has no correlation with hepatitis B virus replication activity and disease progression.

关 键 词：乙肝病毒 抗平滑肌抗体 肝硬化 自身免疫性肝病 

分 类 号：R446.6[医药卫生—诊断学]