痛风过程中微小RNA、长链非编码RNA和环状RNA介导降尿酸、抗炎及调控骨代谢的协同调节作用  

MicroRNA,long non-coding RNA and circular RNA mediate the mechanism of decreasing uric acid,anti-inflammation and regulating bone metabolism in gout

作　　者：邵子晨 李华南[2] 顾兵 章晓云 孙伟康[1] 刘永钱 甘斌 Shao Zichen;Li Huanan;Gu Bing;Zhang Xiaoyun;Sun Weikang;Liu Yongqian;Gan Bin(Clinical Medical College of Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi Province,China;Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi Province,China;School Pharmacy,Jiangxi Science and Technology Normal University,Nanchang 330013,Jiangxi Province,China;Department of Orthopedics,Ruikang Hospital,Guangxi University of Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]江西中医药大学临床医学院,江西省南昌市330004 [2]江西中医药大学附属医院,江西省南昌市330004 [3]江西科技师范大学药学院,江西省南昌市330013 [4]广西中医药大学附属瑞康医院骨科,广西壮族自治区南宁市530011

出　　处：《中国组织工程研究》2023年第5期765-771,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(81860857,82060871),项目负责人:李华南;江西省自然科学基金(20202BAB206071),项目负责人:李华南;江西省教育厅科学技术研究项目(GJJ190582),项目负责人:顾兵;江西省邓运明国医名师工作室(赣人社字〔2021〕201号),项目负责人:李华南。

摘　　要：背景:在过去十年中,对痛风发病机制、影响、诊断方法和治疗的理解方面取得了重大进展,但痛风的发病机制尚未明确。大量实验研究表明微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)与痛风的发生发展密切相关。目的:阐述微小RNA、长链非编码RNA和环状RNA在痛风不同进程中作用机制的进展。方法:以“痛风;高尿酸血症;痛风性关节炎;长链非编码RNA;微小RNA;环状RNA;RNA”为中文检索词,以“Gout;Arthritis,Gouty;Gouty Arthritis;Arthritides,Gouty;Gouty Arthritides;Hyperuricemia;RNA;Gene Products,RNA;RNA Gene Products;RNA,Non Polyadenylated;Non Polyadenylated RNA;Ribonucleic Acid”为英文检索词,分别检索中国知网、PubMed、万方、Embase、维普等数据库,检索文献时限为2013-2022年。通过阅读文献标题及摘要进行筛选,剔除低质量、重复性、内容不相关的文献,纳入相关性较高的53篇文献进行综述。结果与结论:微小RNA、长链非编码RNA和环状RNA有望成为降低尿酸水平、修复免疫平衡、减轻炎症反应及调控破骨细胞活化的新靶点、新策略,成为痛风治疗的生物标志物。启发在后续的研究中,应当加强表观遗传学在人体作用机制的研究,同样应该重视对于多种非编码RNA的协同调节作用的探讨。BACKGROUND:In the past decade,significant progress has been made in the understanding of the pathogenesis,effects,diagnostic methods and treatments of gout,but the pathogenesis of gout has not yet been clarified.A large number of experimental studies have shown that microRNAs(miRNAs),long non-coding RNAs(lncRNAs)and circular RNAs(circRNAs)are closely related to the occurrence and development of gout.OBJECTIVE:To review the mechanism of miRNA,lncRNA and circRNA in different stages of gout development.METHODS:The Chinese search terms were“Gout;Hyperuricemia;Gouty Arthritis;lncRNA;miRNA;circRNA;RNA”and the English search terms were“Gout;Arthritis,Gouty;Gouty Arthritis;Arthritides,Gouty;Gouty Arthritides;Hyperuricemia;RNA;Gene Products,RNA;RNA Gene Products;RNA,Non Polyadenylated;Non Polyadenylated RNA;Ribonucleic Acid.”PubMed,Embase,CNKI,WanFang,VIP and other databases were retrieved respectively.The search time range was 2013 to 2022.By reading the titles and abstracts of the literature,the low-quality,repetitive and irrelevant articles were excluded and 53 highly relevant articles were included in the review.RESULTS AND CONCLUSION:MiRNA,lncRNA,and circRNA are expected to become new targets and strategies for reducing uric acid levels,repairing immune balance,reducing inflammation and regulating osteoclast activation,which will become biomarkers for gout treatment.In the follow up study,we should strengthen the research on the mechanism of epigenetics in human body and also pay attention to the co-regulation of many kinds of non-coding RNAs.

关 键 词：长链非编码RNA 痛风 高尿酸血症 环状RNA 炎症反应 骨代谢 信号通路 微小RNA 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R589.7