低氧训练对氧感知通路的影响  

Effect of hypoxic training on the oxygen sensing pathway

作　　者：刘源[1] Liu Yuan(Shandong Jianzhu University,Jinan 250101,Shandong Province,China)

机构地区：[1]山东建筑大学,山东省济南市250101

出　　处：《中国组织工程研究》2023年第5期793-798,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:低氧训练是一种利用缺氧和运动双重刺激,调动运动员潜能,进而提高运动成绩的训练方法。氧感知即细胞对氧气的感知力以及对氧气的适应力,该能力由细胞中低氧诱导因子等多个关键因子调控,进而形成一条氧气感知通路,该通路在低氧训练发挥重要作用。目的:从低氧训练中机体细胞如何感知氧和对缺氧的适应性出发,探讨低氧训练促进健康的生理学机制。方法:在中国知网、Pub Med数据库中进行相关文献检索,中文检索词为“氧感知,低氧训练,低氧诱导因子”,英文检索词为“oxygen-sensing,hypoxic training,hypoxia inducible factor”。通过阅读文题、摘要和全文后,最终纳入50篇文献进行综述。结果与结论:低氧诱导因子是氧感知通路中的重要调节因子。低氧训练可显著上调低氧诱导因子1的表达,增强组织中的葡萄糖代谢、氧气的转运以及血管生成,为低氧训练介导氧感知通路预防和缓解由缺氧引起的心血管疾病提供理论支持。未来低氧诱导因子信号通路可能作为一种新的治疗靶点在改善人体组织功能中发挥其价值,并且低氧诱导因子对细胞感应和响应氧气水平的阐明为生物学和医学开辟了新领域。BACKGROUND:Hypoxic training is a training method that utilizes the dual stimulation of hypoxia and exe rcise to mobilize the potential of athletes and improve athletic performance.Oxygen sensing is the ability of cells to sense oxygen and adapt to oxyge n,which is regulated by many key factors in cells,such as hypoxia-inducible factors,which in turn form an oxygen sensing pathway.This pathway plays an important role in hypoxic training.OBJECTIVE:From the perspective of how the body cells perceive oxygen and adapt to hypoxia during hypoxic training,to explore the physiological mechanism by which hypoxic training promotes exercise health and improves exercise performance.METHODS:A lite rature search of CNKI and PubMed was conducted using the keywords of "oxygen-sensing,hypoxic training,hypoxia inducible factor" in Chinese and Englis h,respectively.After title,abstra ct and main text reading,50 articles were finally included for review.RESULTS AND CONCLUSION:Hypoxia-inducible facto rs are important regulators in the oxygen sensing pathway.Hypoxic training can significantly upregulate the expression of hypoxia-inducible factor-1,enhance glucose metabolism,oxygen transport and angiogenesis in tissues,providing theoretical suppo rt for hypoxic training to prevent and alleviate hypoxia-induced cardiovascular diseases through the oxygen sensing pathway.The hypoxia-inducible factor signaling pathway may play its value as a new therapeutic target to improve human tissue function in the future and the elucidation of the mechanism by which hypoxiainducible factors act on cellular sensing and response to oxygen levels opens up new fields for biology and medicine.

关 键 词：氧感知 低氧训练 低氧诱导因子 细胞 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] G808.1[文化科学—体育训练]