大麻二酚抗肿瘤作用机制新进展  

New progress in the anti-tumor mechanism of cannabidiol

作　　者：汤云云 王爽[1] 岳琦[1] TANG Yunyun;WANG Shuang;YUE Qi(Department of Obstetrics and Gynecology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,150000,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第四医院妇产科,黑龙江哈尔滨150000

出　　处：《肿瘤药学》2022年第3期324-330,共7页Anti-Tumor Pharmacy

基　　金：哈尔滨医科大学附属第四医院特别资助项目(HYDSYTB201925)。

摘　　要：植物大麻是大麻素的主要来源。大麻素中的主要化合物之一大麻二酚(CBD)近年来备受关注。CBD不仅具有非精神活性作用,还具有抗增殖、促凋亡、抗侵袭、抗血管生成、抗炎和免疫调节等作用,使得其在抗肿瘤临床应用方面具有一定的优势。本文主要介绍CBD、CBD相关受体及其在各系统主要肿瘤疾病中的多靶点抗肿瘤作用机制新进展,以期为新的抗肿瘤治疗策略和研究方向提供参考。Cannabis plants are the main source of cannabinoids.Cannabidiol(CBD),one of the main compounds in cannabinoids,has attracted much attention in recent years.CBD not only has non-psychoactive effects,but also has effects of anti-proliferation,pro-apoptosis,cytotoxicity,anti-invasion,anti-angiogenesis,anti-inflammation and immunomodulation,which makes it have some advantages in anti-tumor clinical application.This article mainly introduced the new progress of CBD,CBD-related receptors and their multi-target anti-tumor mechanisms in major tumors,in order to provide references for new anti-tumor therapy strategies and research directions.

关 键 词：大麻素 大麻二酚 多靶点效应 抗肿瘤治疗 

分 类 号：R96[医药卫生—药理学]