单采血小板献血者不良反应的综合因素分析  

Comprehensive factors in adverse reactions to apheresis platelet donation in Lanzhou area

作　　者：南党斌 陈莉 雷蕾 郭建强[1] 马国宁[1] 吴康乐[1] 张支凤 NAN Dangbin;CHEN Li;LEI Lei;GUO Jianqiang;MA Guoning;WU Kangle;ZHANG Zhifeng(Gansu Red Cross Blood Center,Lanzhou 730046,China)

机构地区：[1]甘肃省红十字血液中心,兰州甘肃730046 [2]兰州市第二人民医院

出　　处：《中国输血杂志》2022年第6期633-636,共4页Chinese Journal of Blood Transfusion

基　　金：甘肃卫生行业科研计划的资助(GSWSKY-2019-36)。

摘　　要：目的通过分析引起单采血小板献血不良反应的综合因素,为有效预防献血不良反应提供依据和方式方法。方法统计2012~2019年兰州地区所有的单采血小板献血者和272例发生献血反应献血者,分析各种诱发献血不良反应的因素,根据性别、民族、职业、年龄、体重、献血量及献血次数进行统计学分析。结果各种诱发单采献血者献血不良反应的因素中,抗凝剂反应为第1位,占32.4%(88/272);女性、学生容易发生献血反应;各年龄段中,18~25岁最容易发生献血不良反应,占53.68%(10572/35265),年龄段与献血不良反应有统计学意义(P<0.05);不同体重间的献血者比较都有统计学意义,体重越轻,发生献血不良反应的概率越大(P<0.05),初次献血者与重复献血者发生献血不良反应有统计学意义(P<0.05),献血量与献血不良反应无统计学意义。结论单采献血者抗凝剂反应占整个献血不良反应因素的首位,需重点关注女性、学生、年龄较小、体重较轻、初次献血的献血者,分别采取相应的干预措施来预防献血不良反应的发生。Objective To analyze the comprehensive factors causing adverse reactions to apheresis platelet donation(ARAPD),so as to provide references for effective prevention of ARAPD.Methods The 272 cases of ARAPD from 2012 to 2019 in Lanzhou were statistically analyzed,and factors that induced ARAPD were studied.Statistical analysis were performed according to the gender,nationality,occupation,age,weight,donation units,and number of donations.Results As to the factors inducing ARAPD,anticoagulant reactions accounted for the first(32.4%,88/272).Women and students were prone to develop ARAPD.Among all age groups,18~25 years old were most likely to develop ARAPD(53.68%,10572/35265).The incidence of ARAPD were significantly different by ages and weights(P<0.05),and donors with lighter weight were more prone to develop ARAPD(P<0.05).The incidence of ARAPD were also significantly different between first-time and repeated donors(P<0.05),but not among the donation units.Conclusion The anticoagulant reactions are the leading reason for ARAPD.For female,student,young,light-weight,and first-time blood donors,special attention should be paid and corresponding interventions taken to them.

关 键 词：单采血小板 献血者 不良反应 综合因素 

分 类 号：R558[医药卫生—血液循环系统疾病] R457.13[医药卫生—内科学]