免疫性血小板输注无效发生机制和解决策略  

Mechanism and transfusion strategy of immunogenic platelet transfusion refractoriness

作　　者：赛娟 田力 SAI Juan;TIAN Li(Key Laboratory of Transfusion Adverse Reactions,Chinese Academy of Medical Sciences,Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College,Chengdu 610052,China)

机构地区：[1]中国医学科学院北京协和医学院输血研究所,中国医学科学院输血不良反应研究重点实验室,四川成都610052

出　　处：《中国输血杂志》2022年第6期677-682,共6页Chinese Journal of Blood Transfusion

基　　金：四川省国际科技创新合作/港澳台科技创新合作项目(2020YFH0024)。

摘　　要：血小板输注是血液科、肿瘤科等患者治疗血小板减少症不可替代的方法,然而,此类患者现阶段面临的难题是免疫性血小板输注无效。改善免疫性输注无效患者血小板输注效果需要制定合理的解决策略并阐明机制。本文旨在综述免疫性血小板输注无效发生机制和解决策略的研究进展和前景,为免疫性输注无效患者提供合理输注策略,从而改善血小板输注效果。Platelet transfusion is an irreplaceable method to treat patients with platelet reduction in Hematology Department and Oncology Department.However,immunogenic platelet transfusion refractoriness is a huge challenge to patients who require repeatedly platelet transfusion.Therefore,mechanisms and reasonable transfusion strategies should be formulated to improve immunogenic platelet transfusion outcomes.This article aims to review the research progress and prospects concerning mechanisms and solutions of immunogenic platelet transfusion refractoriness,and provide rational transfusion strategies for platelet transfusion refractoriness patients,thus improving platelet transfusion outcomes.

关 键 词：血小板输注无效 免疫性因素 发生机制 解决策略 

分 类 号：R331.143[医药卫生—人体生理学] R457.1[医药卫生—基础医学]