细胞力学在皮肤科的研究进展  

Cell mechanics in dermatology

作　　者：冯华 高英姝[1] 李清[1] 孙联文[2] Feng Hua;Gao Yingshu;Li Qing;Sun Lianwen(Department of Dermatology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Key Laboratory of Biomechanics and Mechanobiology,Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China)

机构地区：[1]首都医科大学附属北京天坛医院皮肤科,北京100070 [2]生物力学与力生物学教育部重点实验室,北京市生物医学工程高精尖创新中心,北京航空航天大学生物与医学工程学院,北京100083

出　　处：《中华皮肤科杂志》2022年第7期641-644,共4页Chinese Journal of Dermatology

摘　　要：细胞力学是一门新兴的交叉学科,以研究细胞的力学特性与细胞生命活动以及组织、器官、机体生理过程的关系为主。通过对力学信号的感受和响应机制,细胞参与皮肤、骨、眼等多器官组织的生理活动以及疾病的发生发展,包括皮肤组织再生、重建、适应性变化和多种皮肤病的发病,因此成为近年皮肤病研究的热点。本文综述近年来细胞力学的基础研究和其在瘢痕、压疮、白癜风、皮肤肿瘤、毛发疾病等方面的研究和应用进展,为皮肤病治疗提供可能的方法和策略。Cell mechanics is a new interdiscipline,which focuses on the relationship between cell mechanical properties and cell behaviors,as well as physiological processes in tissues,organs and the body.Through the perception of and response to mechanical signals,cells participate in physiological activities of skin,bones,eyes and other organs,and the occurrence and development of diseases,including the regeneration,reconstruction and adaptive changes of skin tissues and the pathogenesis of various skin diseases.Cell mechanics has become a hot spot in the research of skin diseases in recent years.This review summarizes recent progress in cell mechanics-associated basic research,as well as in its research and application in scars,bedsores,vitiligo,skin tumors,hair diseases,etc.,aiming to provide possible methods and strategies for the treatment of skin diseases.

关 键 词：皮肤病学 瘢痕 皮肤肿瘤 秃发 细胞力学 

分 类 号：R751[医药卫生—皮肤病学与性病学]