猪δ冠状病毒主要蛋白功能研究进展  

Research Progress on the Function of Major Proteins of Porcine Delta Coronavirus

作　　者：黄瑶 曹飞 李凤琴 谷思睿[1] 王玉玲 岳健国 徐志文 周远成[5] 朱玲[1] HUANG Yao;CAO Fei;LI Fengqin;GU Sirui;WANG Yuling;YU Jianguo;XU Zhiwen;ZHOU Yuancheng;ZHU Ling(Sichuan Key Laboratory of Animal Diseases and Human Health,College of Animal Medicine,Sichuan Agricultural University,Chengdu 611130,China;Sichuan Rongzhou Animal Pharmaceutical Co.,Ltd.,Zigong 643102,China;Xichang University,Xichang 615013,China;Chengdu Animal Disease Prevention and Control Center,Chengdu 611331,China;Animal Breeding and Genetics Key Laboratory of Sichuan Province,Sichuan Animal Science Academy,Chengdu 610066,China)

机构地区：[1]四川农业大学动物医学院动物疫病与人类健康四川省重点实验室,成都611130 [2]四川荣州动物药业有限公司,自贡643102 [3]西昌学院,西昌615013 [4]成都市动物疫病预防控制中心,成都611331 [5]四川省畜牧科学研究院畜禽生物制品四川省重点实验室,成都610066

出　　处：《病毒学报》2022年第3期738-745,共8页Chinese Journal of Virology

基　　金：四川省科技计划项目(项目号:2020YFN009),题目:规模猪场新发病原精准检测删除技术创建及示范应用;四川省农业厅农业产业技术体系(项目号:CARS-SVDIP),题目:国家农业产业技术体系四川兽药创新团队专项;四川省科技厅重点研发项目(项目号:2018NZ0150),题目:优质生猪工程产业链关键技术集成与示范。

摘　　要：猪δ冠状病毒(Porcine Deltacoronavirus,PDCoV)是冠状病毒科,δ冠状病毒属成员,为单股正链RNA病毒。由于猪δ冠状病毒是一种新型肠道冠状病毒(于2012年首次报道),目前对其研究较少,缺少商品化的疫苗。对疫病的防控无疫苗可用,一旦发病,会对猪场造成严重损失。本文综述了已有的关于猪δ冠状病毒结构蛋白、辅助蛋白、非结构蛋白等的特点和功能,以期为深入研究PDCoV致病机制和免疫机理提供参考,从而有助于其疫苗研发。Porcine Deltacoronavirus(PDCoV)is a member of the family of coronaviridae,belonging to the genusδcoronavirus.As porcine delta coronavirus is a new type of enterocoronavirus(first reported in 2012),there is little research on it and lack of commercial vaccine.There is no vaccine available for the prevention and control of the disease.Once the disease occurs,it will cause serious losses to the pig farm.In this paper,the characteristics and functions of structural protein,auxiliary protein and nonstructural protein of porcine delta coronavirus were reviewed in order to provide reference for further research on pathogenesis and immune mechanism of pdcov vaccine.

关 键 词：猪δ冠状病毒(PDCoV) 结构蛋白 辅助蛋白 非结构蛋白 功能研究 

分 类 号：S855.3[农业科学—临床兽医学]