艾司洛尔联合乌司他丁治疗胃肠道肿瘤术后穿孔的效果观察  

Clinical effect of Esilol combined with Uselastatin in postoperative patients with cavity organ perforation

作　　者：袁宽道 王莉[1] 周湘哲[1] 田瑞兆[1] 张丽丽 YUAN Kuandao;WANG Li;ZHOU Xiangzhe;TIAN Ruizhao;ZHANG Lili(Department of Critical Care Medicine,Gansu Cancer Hospital,Lanzhou,Gansu 730050,China)

机构地区：[1]甘肃省肿瘤医院危重症医学科,甘肃兰州730050

出　　处：《医药前沿》2022年第15期16-18,共3页Journal of Frontiers of Medicine

摘　　要：目的:分析胃肠道肿瘤术后穿孔患者采用艾司洛尔联合乌司他丁治疗效果。方法:选取2017年6月—2021年6月甘肃省肿瘤医院收治的88例胃肠道肿瘤术后穿孔患者,按照随机数字表法将其分为三组,即对照组24例,采用常规治疗;乌司他丁组30例,在常规治疗的基础上采用乌司他丁治疗;联合组34例,在常规治疗的基础上,采用乌司他丁联合艾司洛尔治疗。比较三组患者治疗疗效、治疗前后血清学指标及氨基末端B型利钠肽前体(NTProBNP)水平变化。结果:联合组患者肿瘤坏死因子-α水平、白细胞介素水平、治疗有总效率优于其他两组,NT-ProBNP水平远低于其他两组,差异有统计学意义(P<0.05)。结论:对胃肠道肿瘤术后穿孔患者,采用艾司洛尔+乌司他丁治疗,既可以提高患者的治疗效果,又能改善患者的血清学指标,还能降低NT-ProBNP水平,从而保护患者的心肌功能。Objective To analyze the effect of Esmolol+Ulinastatin on postoperative myocardial protection in patients with postoperative perforation of gastrointestinal tumors.Methods A total of 88 patients with gastrointestinal tumor perforation after surgery admitted to Gansu Cancer Hospital from June 2017 to June 2021 were selected.They were divided into three groups according to random number table method,namely,control group(n=24),ulinastatin group(n=30),combined group(n=34).The therapeutic effect,serum indexes and the level of n-terminal B-type natriuretic peptide precursor(NT-ProBNP)before and after treatment in three groups were compared.Results The tumor necrosis factor-αvalue,interleukin value and treatment efficiency of the combined group were better than the other two groups,the level of NT-ProBNP in the combined group was much lower than the other two groups,the difference was statistically significant(P<0.05).Conclusion For patients with gastrointestinal tumor perforation after surgery,the use of esmolol+ulinastatin treatment can improve the therapeutic effect of patients,and improve the patient’s serum indicators,but also reduce the level of NT-ProBNP,so as to protect the patient’s myocardial function.

关 键 词：空腔脏器穿孔 脓毒性休克 艾司洛尔 乌司他丁 心肌功能 

分 类 号：R441.9[医药卫生—诊断学]