中药药效物质辨析技术:现状与未来  

Identification of active substances from Traditional Chinese Medicine:state-of-the-art and perspectives

作　　者：武雨含 李敏 刘豪 王毅[1,2] WU YuHan;LI Min;LIU Hao;WANG Yi(Department of Chinese Medicine Science&Engineering,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Innovation Center in Zhejiang University,State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]浙江大学药学院中药科学与工程学系,杭州310058 [2]天津中医药大学,组分中药国家重点实验室浙江大学交叉创新中心,天津301617

出　　处：《中国科学：生命科学》2022年第6期943-956,共14页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:82173941);国家中医药管理局中医药创新团队及人才支持计划项目(批准号:ZYYCXTD-D-202002)资助。

摘　　要：中医药在心脑血管疾病、糖尿病等慢性复杂性疾病防治上具有独特优势,在抗击新冠肺炎疫情等突发重大传染性疾病中发挥了重要作用.如何从复杂中药物质体系中快速辨析其中的药效物质是中药现代化研究的核心科技问题之一.本文归纳了中药药效物质发现策略,总结了常用于中药药效物质发现的多尺度筛选模型,展望了中药药效多模态辨识等创新技术发展方向,为开展中药药效物质研究提供可借鉴的思路与可行的技术手段.Traditional Chinese medicine(TCM)has demonstrated unique advantages in the prevention and treatment of chronic and complex diseases such as cardiovascular and cerebrovascular diseases and diabetes.It has also played a major role in the fight against sudden infectious diseases such as COVID-19.Therefore,how to quickly identify effective constituents from the complex system is the most critical issue in the study of modernization of TCM.Based on this,this article summarizes the rapid identification strategies and multiscale screening models,which provides ideas for analyzing the scientific connotation and explaining the mechanism of TCM.

关 键 词：中药药效物质 多模态辨识 化学生物学 生物色谱 高内涵筛选 

分 类 号：R285[医药卫生—中药学]