口蹄疫病毒蛋白颉颃宿主天然免疫的分子机制  

Molecular mechanism of antagonistic effect of Foot-and-mouth disease virus self-protein on host innate immunity

作　　者：武艺 李璐[1,2] 柴瑞兰 靳慧茹 王申元 凌宇[1,2] 刘羿羿 张焱如[1,2] 周欢敏 刘春霞[1,2] 曹俊伟 WU Yi;LI Lu;CHAI Ruilan;JIN Huiru;WANG Shenyuan;LING Yu;LIU Yiyi;ZHANG Yanru;ZHOU Huanmin;LIU Chunxia;CAO Junwei(College of Life Sciences,Inner Mongolia Agricultural University,Hohhot 010018,China;Laboratory of Biological Manufacturing of Inner Mongolia,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学生命科学学院,呼和浩特010018 [2]内蒙古自治区生物制造重点实验室,呼和浩特010018

出　　处：《黑龙江畜牧兽医》2022年第10期23-29,133,共8页Heilongjiang Animal Science And veterinary Medicine

基　　金：内蒙古自然科学基金项目(2020MS03048);内蒙古科技厅计划项目(201702071)。

摘　　要：口蹄疫(foot-and-mouth disease,FMD)是由口蹄疫病毒(Foot-and-mouth disease virus,FMDV)感染引起的急性、高传染性的牲畜疾病,爆发期间给养殖业造成重大经济损失。当FMDV进入宿主体内时会被免疫系统识别,Ⅰ型和Ⅲ型干扰素会介导增强免疫反应。FMDV通过多种途径抑制抗病毒应答反应,其中包括在转录和翻译水平上抑制干扰素的产生;劫持、裂解宿主蛋白或干扰宿主蛋白的表达;阻断天然免疫过程中蛋白质的翻译后修饰;调节自噬;抑制应激颗粒(stress granules,SGs)的形成。本文综述了FMDV蛋白颉颃抗宿主免疫的相关机制,以期对FMDV致病机理有一个全面的认识,为FMDV的防治提供理论基础。Foot-and-mouth disease(FMD)is an acute and highly contagious livestock disease caused by Foot-and-mouth disease virus,which causes significant economic losses during the disease outbreak.When FMDV enters the host,it is recognized by the immune system,and typeⅠandⅢinterferons mediate an enhanced immune response.FMDV inhibits antiviral response through multiple pathways,including in⁃hibiting the production of interferon at the transcriptional and translational level,hijacking,cleaving or interfering with the expression of host protein,blocking post-translational modification of proteins during natural immunity,regulating autophagy,and inhibiting the formation of stress granules(SGs).This article reviewed the strategies against host immunity,in order to have a comprehensive understanding of the pathogenic mechanism of FMDV and provided a theoretical basis for the prevention and treatment of FMDV.

关 键 词：口蹄疫病毒 免疫 天然免疫 蛋白质 干扰素 颉颃 自噬 

分 类 号：Q955[生物学—动物学]