吲唑酰胺类合成大麻素的EI质谱特征分析  

Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids

作　　者：徐仿敏 李海波[2] 魏万里 王瑞花[4] 刘凌云 李强[2] XU Fang-min;LI Hai-bo;WEI Wan-li;WANG Rui-hua;LIU Ling-yun;LI Qiang(Institute of Forensic Science,Public Security Bureau of Jiangyin,Jiangyin 214431,China;Institute of Forensic Science,Public Security Bureau of Changzhou,Changzhou 213003,China;Institute of Forensic Science,Public Security Bureau of Wuxi,Wuxi 214001,China;Institute of Forensic Science,Ministry of Public Security,Beijing 110038,China)

机构地区：[1]江苏省江阴市公安局物证鉴定室,江苏江阴214431 [2]江苏省常州市公安局物证鉴定所,江苏常州213003 [3]江苏省无锡市公安局物证鉴定所,江苏无锡214001 [4]公安部物证鉴定中心,北京110038

出　　处：《分析测试学报》2022年第7期1030-1035,共6页Journal of Instrumental Analysis

基　　金：中央公益性科研院所基本科研业务费专项资金项目(2021JB007)。

摘　　要：采用气相色谱-质谱联用技术(GC-MS)对9种吲唑酰胺类合成大麻素(MDMB-CHMINACA、5FAB-PINACA、5F-AMB、AB-CHMINACA、AB-FUBINACA、AB-PINACA、MDMB-FUBINACA、AMBFUBINACA、ADB-BUTINACA)在电子轰击(EI)电离模式下产生的主要碎片离子和碎裂过程进行分析,并对所获得的质谱图进行解析,推测该类物质的EI碎裂规律。结果表明,在EI模式下,吲唑酰胺类合成大麻素的吲唑3号位酰胺基C—N键的断裂是主要碎裂方式,在碎裂过程中还存在麦氏重排。该研究总结了吲唑酰胺类合成大麻素在EI模式下的主要碎片离子和质谱特征,归纳了EI的特征碎裂规律,可为吲唑酰胺类合成大麻素的结构推断与鉴定提供参考。A gas chromatography-mass spectrometry(GC-MS)was applied to investigate the mass fragmentation characteristics of 9 indazole-3-carboxamide analogues synthetic cannabinoids in electron ionization(EI),including MDMB-CHMINACA,5F-AB-PINACA,5F-AMB,ABCHMINACA,AB-FUBINACA,AB-PINACA,MDMB-FUBINACA,AMB-FUBINACA and ADB-BUTINACA.The obtained mass spectra were analyzed and the EI fragmentation patterns of indazole-3-carboxamide analogues synthetic cannabinoids were speculated.Results showed that in the EI mode,the C—N cleavage of the amide group connected to the indazole ring at position 3 is the main fragmentation pathway,and the McLafferty rearrangement was happened during the fragmentation.The main fragmentation ions and mass fragmentation characteristic of indazole-3-carboxamide analogues synthetic cannabinoids in EI modes were summarized in this paper,which is useful for identification on the new psychoactive substances of unknown indazole-3-carboxamide analogues synthetic cannabinoids in practical work.

关 键 词：新精神活性物质 合成大麻素 吲唑酰胺类 气相色谱 质谱特征 

分 类 号：O657.63[理学—分析化学] S859.81[理学—化学]