加味参芪地黄汤联合前列地尔治疗慢性肾衰竭患者的疗效  

Effect of Modified Shenqi Dihuang Decoction Combined with Alprostadil on Patients with Chronic Renal Failure

作　　者：马浩[1] 王春丽[1] 张慧敏[2] 强昂 MA Hao;WANG Chun-li;ZHANG Hui-min(Department of Nephrology,Baoji Hospital of traditional Chinese Medicine,Baoji Shaanxi 721000)

机构地区：[1]宝鸡市中医医院肾病科,陕西宝鸡721000 [2]宝鸡市中医医院静配中心,陕西宝鸡721000 [3]宝鸡市第二中医医院骨科,陕西宝鸡721000

出　　处：《医学临床研究》2022年第5期756-759,共4页Journal of Clinical Research

摘　　要：【目的】探讨加味参芪地黄汤联合前列地尔治疗对慢性肾衰竭患者的肾功能、炎症指标及晚期蛋白质氧化产物(AOPP)水平的影响。【方法】在本院接受治疗的100例慢性肾衰竭患者随机分为中药组(n=50)和西药组(n=50),其中西药组给予前列地尔治疗,中药组给予加味参芪地黄汤联合前列地尔治疗。比较两组患者肾功能[血肌酐(SCr)、尿素氮(BUN)、24h尿蛋白],AOPP水平,炎症指标[C反应蛋白(CRP)、白细胞介素-17(IL-17)、白细胞介素-6(IL-6)]的变化以及临床疗效和不良反应发生情况。【结果】与治疗前比较,两组患者治疗后血清SCr、BUN、24h尿蛋白、AOPP、CRP、IL-17、IL-6水平均明显降低(P<0.05),且中药组较西药组降低更为明显(P<0.05);中药组总有效率为86.00%(43/50),明显高于西药组的62.00%(31/50)(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】加味参芪地黄汤联合前列地尔治疗慢性肾衰竭,可有效调节患者炎症指标,降低AOPP水平,改善肾功能及氧化应激状态,且安全有效。【Objective】To investigate the effects of modified Shenqi Dihuang Decoction combined with alprostadil on renal function,inflammatory indexes and the level of advanced protein oxidation products(AOPP)in patients with chronic renal failure.【Methods】A total of 100 patients with chronic renal failure treated in our hospital were randomly divided into traditional Chinese medicine group(50 cases)and Western medicine group(50 cases).The western medicine group was treated with alprostadil,and the traditional Chinese medicine group was treated with modified Shenqi Dihuang Decoction combined with alprostadil.The changes of renal function[serum creatinine(SCR),urea nitrogen(BUN),24h urinary protein],AOPP level,inflammatory indexes[C-reactive protein(CRP),interleukin-17(IL-17),interleukin-6(IL-6)]and clinical efficacy and adverse reactions were compared between the two groups.【Results】Compared with before treatment,serum SCR,BUN,24h urinary protein,AOPP,CRP,IL-17 and IL-6 decreased significantly in the two groups after treatment(P<0.05),and the decrease in the traditional Chinese medicine group was more obvious than that in the western medicine group(P<0.05);The total effective rate of traditional Chinese medicine group was 86.00%(43/50),which was significantly higher than that of Western medicine group[62.00%(31/50)(P<0.05)];There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】The modified Shenqi Dihuang Decoction combined with alprostadil in the treatment of chronic renal failure can effectively regulate the inflammatory indexes,reduce the level of AOPP,improve renal function and oxidative stress,and is safe and effective.

关 键 词：肾功能衰竭 慢性/中西医结合疗法 前列地尔/治疗应用 治疗结果 

分 类 号：R692.5[医药卫生—泌尿科学]