钯催化的烯烃异构化反应  

Pd-Catalyzed Isomerization of Alkenes

作　　者：陈宏超 吴奕晨 于洋 王鹏[2,3,4] Chen Hong-Chao;Wu Yichen;Yu Yang;Wang Peng(College of Science,Shanghai University,Shanghai 201900;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Shanghai 200032;CAS Key Laboratory of Energy Regulation Materials,Shanghai Institute of Organic Chemistry,Shanghai 200032;School of Chemistry and Material Sciences,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024)

机构地区：[1]上海大学理学院,上海201900 [2]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032 [3]中国科学院上海有机化学研究所中国科学院能量调控材料重点实验室,上海200032 [4]中国科学院大学杭州高等研究院化学与材料科学学院,杭州310024

出　　处：《有机化学》2022年第3期742-757,共16页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22171277,22101291,21821002);上海“启明星”(No.20QA1411400)资助项目.

摘　　要：烯烃异构反应可以从简单烯烃出发,通过对碳碳双键立体选择性或者位置选择性调控,实现内烯烃化合物尤其其他方法难以构建的多取代烯烃的高效合成,原子经济性高.详细介绍了钯催化烯烃异构化反应的反应机制,系统总结了钯催化的烯烃顺反异构和位置选择性异构反应,以及其在药物分子和天然产物合成中的应用.Starting from commercially available simple olefins,alkene isomerization could realize the efficient construction of multi-substituted alkenes,which might be difficult to access with other synthetic methods,in an atom-economic manner via the stereoselective or positional-selective modulation of the carbon-carbon double bonds.The palladium catalyzed stereoselective(Z/E)and the positional selective isomerization reactions of alkenes are summarized.The mechanistic perspectives,and their synthetic applications in the synthesis of drug molecules and natural products are discussed in detail.

关 键 词：钯催化 烯烃 碳碳双键 异构 

分 类 号：O621.251[理学—有机化学]