可回收铋配合物催化氮亲核试剂与对醌甲基化物1,6-加成:轻松获得N-杂环取代的不对称三芳基甲烷衍生物  

1,6-Addition of Nitrogen Nucleophile to para-Quinone Methides Catalyzed by Recyclable Bismuth Complex:Facile Access to N-Heterocyclic Substituted Unsymmetric Triarylmethane Derivatives

作　　者：刘冬兰 许海燕 杭懿 陆鸿飞 Liu Donglan;Xu Haiyan;Hang Yi;Lu Hongfei(School of Environmental and Chemical Engineering,Jiangsu University of Science and Technology,Zhenjiang,Jiangsu 212100)

机构地区：[1]江苏科技大学环境与化学工程学院,江苏镇江212100

出　　处：《有机化学》2022年第3期796-802,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21901087);江苏省自然科学基金(No.BK20190591)资助项目.

摘　　要：开发了一种用对醌甲基化物(p-QMs)和各种芳香族N-杂环化合物1,6-氮杂-迈克尔加成合成含氮不对称三芳基甲烷衍生物的方法.这种合成方法具有反应条件温和、催化剂负载量可接受、原子经济性、易于放大的特点,并且能够以中等至优异的产率形成N-杂环取代的不对称三芳基甲烷衍生物.此外,铋催化剂可以重复使用多次而不会损失其活性.A useful protocol for the synthesis of nitrogen-containing unsymmetric triarylmethane derivatives through 1,6-aza-Michael addition of para-quinone methides(p-QMs)and various aromatic N-heterocycles was developed.This established synthetic strategy features mild reaction conditions,acceptable catalyst loading,atom economy,easy scale-up and enables the formation of N-heterocyclic-substituted unsymmetric triarylmethane derivatives in moderate to excellent yields.Moreover,the bismuth catalyst can be reused several times without losing of its activity.

关 键 词：可回收的铋催化剂 N-杂环取代的不对称三芳基甲烷衍生物 对醌甲基化物 1 6-迈克尔加成反应 

分 类 号：O621.251[理学—有机化学]