基于原位捕获异腈的Ugi四组分反应及其后修饰串联反应:一锅法合成含氮杂环化合物  

Ugi Four-Component Reaction Based on in-situ Capture of Isocyanide and Post-Modification Tandem Reaction:One-Pot Synthesis of Nitrogen Heterocycles

作　　者：罗享豪 谢益碧 黄年玉 王龙 Luo Xianghao;Xie Yibi;Huang Nianyu;Wang Long(Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials,College of Materials and Chemical Engineering,China Three Gorges University,Yichang,Hubei 443002;Hubei Key Laboratory of Natural Products Research and Development,College of Biological and Pharmaceutical Science,China;Three Gorges University,Yichang,Hubei 443007)

机构地区：[1]三峡大学材料与化工学院无机非金属晶体与能量转换材料重点实验室,湖北宜昌443002 [2]三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室,湖北宜昌443002 [3]湖北三峡实验室,湖北宜昌443007

出　　处：《有机化学》2022年第3期838-846,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21602123);高等学校学科创新引智计划(111计划,No.D20015)资助项目.

摘　　要：报道了一种基于原位捕获异腈的Ugi四组分反应及后修饰串联反应的新策略.根据该反应策略,异腈化物被原位制备,并立即被捕获参与Ugi四组分反应及后续的修饰串联反应.相比之前的报道,该策略在Ugi四组分反应及其后修饰串联反应中实现了基于异腈的原位捕获,解决了反应中异腈化物的不稳定、高毒性和对环境的不友好等问题.温和的反应条件,精简的制备方法,也为异腈参与的Ugi四组分及后修饰串联反应提供了一种绿色无污染的新策略.A novel strategy of Ugi four-component and post-modification tandem reaction based on in-situ capture of isocyanide is reported in this paper.According to this reaction strategy,the isocyanide was prepared in situ and immediately captured to participate in Ugi four-component reaction and the subsequent modification tandem reaction.Compared with the previous reports,based on in-situ capture of isocyanide was realized in the Ugi four-component reaction and post-modification tandem reaction,which solved the problems of isocyanide instability,high toxicity and unfriendly to the environment in the reaction.Mild reaction system conditions and simplified preparation method provide a novel green and pollution-free strategy for the tandem reaction of Ugi four-component and post modification series reaction with isocyanide.

关 键 词：异腈的原位捕获 Ugi四组分反应 后修饰串联反应 绿色异腈化学 一锅法合成 

分 类 号：O626[理学—有机化学]