海绵Spongia sp.中一个新的D环为吡啶环的降海绵烷型二萜  

A New Dinorspongian Diterpene with Pyridyl D-Ring from the Marine Sponge Spongia sp.

作　　者：梁咏倩 廖小建 凌珑 杨雅婷 赵冰心 徐石海 Liang Yongqian;Liao Xiaojian;Ling Long;Yang Yating;Zhao Bingxin;Xu Shihai(College of Chemistry and Materials Science,Jinan University,Guangzhou 510632;College of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006)

机构地区：[1]暨南大学化学与材料学院,广州510632 [2]广东药科大学药学院,广州510006

出　　处：《有机化学》2022年第3期901-904,共4页Chinese Journal of Organic Chemistry

基　　金：国家重点研发计划(Nos.2019YFD0901905,2018YFC0310900);国家自然科学基金(Nos.41876145,81874292,21672084);广州市科技计划(Nos.202102010066,201704030042)资助项目.

摘　　要：在对一种Spongia属海绵的化学成分研究中,分离得到一个新的降海绵烷型二萜dinorspongiapyridine(1)和四个已知化合物2~5.通过核磁共振波谱、单晶X-ray衍射以及对比文献的方法,确定了这些化合物的结构及其绝对构型.化合物1是首次发现的D环为吡啶环的3,4-裂环-3,19-双降海绵烷型二萜类化合物,并对其细胞毒活性进行了测试.此外,对化合物1的生物合成途径也进行了探讨.Chemical investigation of the marine sponge Spongia sp.led to a new dinorspongian diterpene dinorspongiapyridine(1)together with four known compounds 2~5.Compound 1 was the first instance of 3,4-seco-3,19-dinorspongian diterpene bearing a rare pyridyl D-ring system.The structure with absolute configuration of 1 was elucidated by the methods of NMR and X-ray diffraction.In addition,the cytotoxic activities against several cancer cell lines of 1 were evaluated.The plausible biogenetic pathway of 1 was also proposed.

关 键 词：海绵 Spongia 降海绵烷型二萜 吡啶环 

分 类 号：O629.61[理学—有机化学]