头孢曲松致儿童胆囊假性结石合并肝功能损伤1例并文献复习  

Biliary Pseudolithiasis Complicated with Liver Function Injury Induced by Ceftriaxone in a Child:a Case Report and Literature Review

作　　者：朱彦 李志玲 孙华君 Zhu Yan;Li Zhiling;Sun Huajun(Shanghai Children’s Hospital,Children’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200062,China)

机构地区：[1]上海市儿童医院,上海交通大学医学院附属儿童医院,上海200062

出　　处：《儿科药学杂志》2022年第7期14-17,共4页Journal of Pediatric Pharmacy

摘　　要：目的:提高临床对头孢曲松致胆囊假性结石和肝功能损伤的认识,避免过度治疗。方法:对上海市儿童医院1例头孢曲松引起胆囊假性结石的案例进行分析并复习相关文献。结果:患儿在连续使用注射用头孢曲松钠5 d停药3 d后出现右上腹痛,腹部B超示胆囊结石,生化检查示肝酶明显升高,给予保肝药治疗后肝酶明显降低,患儿未再诉腹痛等不适症状;停药38 d后复查腹部B超胆囊结石消失,肝酶恢复正常。结论:头孢曲松致儿童胆囊假性结石的发生率较高,影响因素较多,大多数患儿无症状,因胆囊结石一般可自发消失,如无合并严重并发症不需要特殊处理。Objective:To improve the clinical understanding of biliary pseudolithiasis complicated with liver function injury induced by ceftriaxone,and avoid the excessive treatment.Methods:A case of biliary pseudolithiasis complicated with liver function injury induced by ceftriaxone in Shanghai Children’s Hospital was analyzed and related literature were reviewed.Results:A child was hospitalized with right upper abdominal pain after continuous administration of ceftriaxone for 5 d and drug withdrawal for 3 d.Abdominal ultrasound scan showed gallstone and blood examination showed increased liver enzymes.After treatment with hepatoprotective drugs,the liver enzymes decreased significantly,and the child no longer complained with abdominal pain and other uncomfortable symptoms.After 38 d of treatment,the abdominal ultrasound scan showed that the gallstone disappeared,and the liver enzymes returned to the normal state.Conclusion:The incidence of biliary pseudolithiasis induced by ceftriaxone in children is relatively high,and there are a lot of influencing factors.Most children are asymptomatic,because gallstone generally disappear spontaneously,and no special treatment is required if there are no severe complications.

关 键 词：胆囊假性结石 头孢曲松 病例报道 

分 类 号：R969.3[医药卫生—药理学]