超声联合NCE-MRA评价尿毒症透析功能及对FGF-23、klotho的鉴定分析  

Ultrasound Combined with NCE-MRA to Evaluate the Dialysis Function of Uremia and the Identification Analysis of Serum FGF-23 and klotho

作　　者：刘红[1] 黄俊波[2] 万磊[3] LIU Hong;HUANG Junbo;WAN Lei(Department of Ultrasound Imaging,Xiantao First People’s Hospital Affiliated to Changjiang University,Xiantao 433099,Hubei,P.R.China;Department of Nephrology,Xiantao First People’s Hospital Affiliated to Changjiang University,Xiantao 433099,Hubei,P.R.China;Huangshi Central Hospital of Edong Medical Group,Huangshi 435000,Hubei,P.R.China)

机构地区：[1]长江大学附属仙桃市第一人民医院超声影像科,湖北仙桃433099 [2]长江大学附属仙桃市第一人民医院肾内科,湖北仙桃433099 [3]鄂东医疗集团黄石市中心医院,湖北黄石435000

出　　处：《影像科学与光化学》2022年第4期848-853,共6页Imaging Science and Photochemistry

摘　　要：本文探讨超声联合非对比增强磁共振血管造影(NCE-MRA)评价尿毒症透析患者心血管钙化、左心室内功能及对成纤维细胞生长因子-23(FGF-23)、klotho的鉴定。收集肾内科血液透析中心56例血液透析治疗患者临床资料,超声联合NCE-MRA评价尿毒症透析功能;酶联免疫法测定血清FGF-23、klotho的含量。结果显示:(1)左心室功能显示,与透析前相比,透析后尿毒症患者左室射血分数(LVEF)、左心室舒张末容积(LVEDV)、左心室16节段收缩失同步指数(SDI16)、左心室16节段舒张失同步指数(DDI16)均显著增加(P<0.05);(2)血清FGF-23水平与血肌酐、碱性磷酸酶、磷、钙等含量呈正相关(P<0.05),与残余肾功能、尿素清除指数、klotho蛋白含量等呈负相关(P<0.05)。本研究发现,血液透析可以显著改善尿毒症患者心室内功能,血清FGF-23和klotho蛋白可用于诊断尿毒症透析心血管钙化情况。The purpose of this paper was to evaluate cardiovascular calcification,left ventricular function and identification of serum standard FGF-23(fibroblast growth factor-23)and klotho of uremic dialysis patients as the combination of ultrasound with contrast enhanced magnetic resonance angiography(NCE-MRA).The clinical data of 56 patients undergoing hemodialysis treatment were collected to evaluate the dialysis function of uremia content through ultrasound combined with NCE-MRA was used.The results showed:(1)compared with before dialysis the left ventricular function showed that,the left ventricular ejection fraction(LVEF),diastolic volume(LVEDV),systolic dyssynchrony index(SDI16),and diastolic dyssynchrony index(DDI16)of uremic patients after dialysis were significantly increased(P<0.05);(2)the level of serum standard FGF-23 was positively correlated with the contents of creatinine,alkaline phosphatase,phosphorus,calcium,etc.(P<0.05),and was positively correlated with residual renal function,urea clearance index,the protein content of klotho was negatively correlated(P<0.05).This study found that hemodialysis could significantly improve the intraventricular function of uremic patients;serum FGF-23 and klotho protein could be used to diagnose cardiovascular calcification in uremic dialysis patients.

关 键 词：超声 NCE-MRA评价 尿毒症透析 心血管钙化 心室内功能 成纤维细胞生长因子-23 可溶性klotho蛋白 

分 类 号：R692.5[医药卫生—泌尿科学] R445.1[医药卫生—外科学]