多巴胺联合rhEPO治疗新生儿硬肿症的临床研究  

Clinical study of dopamine in combination with rhEPO in the treatment of neonatal sclerosis

作　　者：熊鹰 Xiong Ying(Department of Pediatrics,Panjin Liaoyou Gemstone Flower Hospital,Panjin Liaoning 124010,China)

机构地区：[1]盘锦辽油宝石花医院儿科,辽宁盘锦124010

出　　处：《保健医学研究与实践》2022年第6期22-25,共4页Health Medicine Research and Practice

摘　　要：目的探讨多巴胺联合重组人促红细胞生成素(rhEPO)治疗新生儿硬肿症的临床疗效。方法选取2017年1月—2021年1月盘锦市某医院收治的新生儿硬肿症患儿112例为研究对象,采用随机数字表法分为rhEPO组与对照组,每组56例。对照组患儿给予多巴胺治疗,rhEPO组患儿给予多巴胺联合rhEPO治疗,2组患儿均持续治疗7 d,随访6个月,比较2组患儿临床疗效、硬肿开始消退时间、硬肿完全消退时间及复温时间;比较2组患儿治疗前后血清肌酐(SCr)、血尿素氮(BUN)水平;比较2组患儿随访3个月与6个月时的心理运动发育指数(PDI)评分、智力发育指数(MDI)评分。结果rhEPO组患儿治疗总有效率为98.21%,高于对照组的85.71%,差异有统计学意义(P<0.05)。rhEPO组患儿硬肿开始消退时间、硬肿完全消退时间及复温时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,2组患儿血清BUN水平均低于治疗前,且rhEPO组低于对照组,差异均有统计学意义(P<0.05)。rhEPO组患儿在随访3个月、6个月时的MDI评分、PDI评分均高于对照组,差异均有统计学意义(P<0.05)。结论多巴胺联合rhEPO治疗新生儿硬肿症疗效显著,可有效改善患儿肾功能,促进疾病恢复,促进患儿智能发育,值得在临床上推广使用。Objective To investigate the clinical efficacy of dopamine combined with recombinant human erythropoietin(rh EPO)in the treatment of neonatal sclerosis.Methods A total of 112 newborns with sclerosis admitted to a hospital in Panjin from January 2017 to January 2021 were selected as subjects,who were assigned to a rh EPO group and a control group using the random number table method,with 56 cases in each group.The children in the control group were treated with dopamine,and the children in the rh EPO group dopamine combined with rh EPO.The children in both groups were treated for 7 d and received a follow-up for 6 months.The clinical efficacy,the time to initial scleromas resolution,the time to complete resolution of the scleromas,and rewarming time were compared.The serum creatinine(SCr)and blood urea nitrogen(BUN)levels before and after treatment were compared between the two groups of children.The psychomotor development index(PDI)scores and mental development index(MDI)scores of the two groups were compared at 3 months and 6 months of follow-up.Results The total effective rate of treatment for children in the rh EPO group was 98.21%,which was higher than that of the control group(85.71%),and the difference was statistically significant(P<0.05).The time to initial scleromas resolution,the time to complete resolution of the scleromas,and rewarming time in the rh EPO group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum BUN levels of children in both groups were lower than those before treatment,and the rh EPO group was lower than the control group,with statistically significant differences(P<0.05).The MDI and PDI scores of children in the rh EPO group were higher than those in the control group at 3 and 6 months of follow-up,and the differences were statistically significant(P<0.05).Conclusion Dopamine in combination with rh EPO is effective in the treatment of neonatal sclerosis,which can effectively improve the renal function of

关 键 词：多巴胺 重组人促红细胞生成素 新生儿硬肿症 肾功能 

分 类 号：R722.1[医药卫生—儿科]