烯烃自由基胺硒化:β-氨基硒醚的简易合成  

Radical Aminoselenation of Styrenes:Facile Access toβ-Amido-selenides

作　　者：殷一樊 李晨 孙凯 刘颖杰 王薪 Yin Yifan;Li Chen;Sun Kai;Liu Yingjie;Wang Xin(Department of Chemistry&Biochemistry,New Mexico State University,New Mexico,88011 USA;School of Pharmacy,Harbin University of Commerce,Harbin 150076;College of Chemistry and Chemical Engineering,Yantai University,Yantai,Shandong 264005)

机构地区：[1]新墨西哥州立大学化学与生物化学系,新墨西哥州88011 [2]哈尔滨商业大学药学院,哈尔滨150076 [3]烟台大学化学化工学院,山东烟台264005

出　　处：《有机化学》2022年第5期1431-1437,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21801007)资助项目.

摘　　要：发展了一种高效的烯烃、二芳基二硒醚和烷基胺的分子间胺硒化策略,在铜盐和高价碘试剂条件下,以较高产率获得一系列的β-氨基硒化物.初步的实验结果表明,反应涉及活性硒自由基中间体,并提出了自由基反应机理.An efficient protocol for the intermolecular amidoselenation of alkenes with diphenyl diselenides and alkyl amines has been developed,affording a series ofβ-amido-selenides in high yields under copper salt and(diacetoxyiodo)benzene(PIDA)conditions.The preliminary experimental results supported the involvement of active selenide radical species,and a radical pathway was therefore proposed for the reaction.

关 键 词：胺硒化 β-氨基硒化物 活性硒化物 自由基 

分 类 号：O621.3[理学—有机化学]