达格列净对血糖控制不佳的2型糖尿病患者血糖波动的影响  

Effect of Dapagliflozin on Blood Glucose Fluctuation in Patients with Type 2 Diabetes Mellitus with Poor Glycemic Control

作　　者：胡玉娟[1] 王尉[2] 徐延德 HU Yujuan;WANG Wei;XU Yande(Department of Outpatient Pharmacy,Jinan Fifth People's Hospital,Jinan,Shandong Province,250000 China;Department of Ward Pharmacy,Jinan Fifth People's Hospital,Jinan,Shandong Province,250000 China)

机构地区：[1]济南市第五人民医院门诊药房,山东济南250000 [2]济南市第五人民医院病房药房,山东济南250000

出　　处：《糖尿病新世界》2022年第11期21-25,共5页Diabetes New World Magazine

摘　　要：目的分析血糖控制不佳的2型糖尿病患者采用达格列净治疗对血糖波动的影响。方法选取2021年1—12月在该院治疗的90例血糖控制不佳的2型糖尿病患者为研究对象,采用随机数表法将其划分为观察组和对照组。对照组采用常规治疗方式,观察组在此基础上采用达格列净治疗。观察比较两组患者临床治疗效果。结果治疗前两组患者各项血糖指标空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)对比,差异无统计学意义(P>0.05);治疗后,观察组较对照组FPG、2 hPG、HbA1c指标水平明显降低,差异有统计学意义(P<0.05)。治疗前,两组患者各项血糖波动指标平均血糖波动幅度(MAGE)、血糖平均水平(MBG)、血糖标准差(SDBG)、最大血糖波动幅度(LAGE)对比,差异无统计学意义(P>0.05);治疗后,观察组MAGE、MBG、SDBG、LAGE指标水平较对照组明显降低,差异有统计学意义(P<0.05)。治疗前,两组患者空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰岛β功能指数(HOMA-β)、葡萄糖输注率(GIR)对比,差异无统计学意义(P>0.05);治疗后,观察组FINS、HOMA-IR指标水平较对照组明显降低,HOMA-β、GIR指标水平明显上升,差异有统计学意义(P<0.05)。观察组不良反应总发生率6.67%,较对照组不良反应总发生率13.33%明显更低,但差异有统计学意义(P>0.05)。结论血糖控制不佳的2型糖尿病患者采用达格列净治疗,能够有效改善患者的血糖指标,缓解胰岛素抵抗,改善胰岛素β功能,提高胰岛素敏感性,有效控制患者血糖波动,并降低低血糖、水肿等发生率。Objective To analyze the effect of dapagliflozin treatment on blood glucose fluctuation in patients with type 2 diabetes mellitus with poor blood glycemic control.Methods A total of 90 patients with type 2 diabetes mellitus with poor blood glycemic control who were treated in the hospital from January to December 2021 were selected as the research objects.They were divided into observation group and control group by random number table method.The control group was treated with conventional treatment,and the observation group was treated with dapagliflozin on this basis.The clinical therapeutic effects of the two groups were observed and compared.Results Before treatment,there was no statistically significant difference in the fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG)and glycosylated hemoglobin(HbA1c)between the two groups of patients(P>0.05).After treatment,the levels of FPG,2 hPG and HbA1c in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the average blood glucose fluctuation range(MAGE),average blood glucose level(MBG),standard deviation of blood glucose(SDBG),and maximum blood glucose fluctuation range(LAGE)between the two groups of patients(P>0.05).After treatment,the levels of MAGE,MBG,SDBG and LAGE in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in various insulin-related indicators between the two groups of patients with fasting insulin(FINS),insulin resistance index(HOMA-IR),pancreatic islet beta function index(HOMA-β),and glucose infusion rate(GIR)(P>0.05).After treatment,the levels of FINS and HOMA-IR in the observation group were significantly lower than those in the control group,while the levels of HOMA-βand GIR were significantly increased,the difference was statistically significant(P

关 键 词：达格列净 2型糖尿病 血糖控制不佳 血糖波动 

分 类 号：R587[医药卫生—内分泌]