三苯基砷/铱催化的非活化一级碳氢键的双硼化反应合成1,1-偕二硼烷  

Synthesis of 1,1-Diboron Alkanes via Diborylation of Unactivated Primary C(sp^(3))—H Bonds Enabled by AsPh_(3)/Iridium Catalysis

作　　者：刘文启 沈振陆[1] 徐森苗 Liu Wenqi;Shen Zhenlu;Xu Senmiao(College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014;State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000)

机构地区：[1]浙江工业大学化学工程学院,杭州310014 [2]中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室,兰州730000

出　　处：《有机化学》2022年第4期1101-1110,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.91956116,21776260)资助项目.

摘　　要：报道了以吡唑作为导向基,三苯基砷/铱催化的活化一级碳氢键的双硼化反应.这一方法能够兼容多种官能团,能够以中等到良好的收率实现一系列1,1-偕二硼烷类化合物的合成.同时,这一方法也能够实现克级规模的反应,所获得的硼化产物能够实现进一步的转化.The AsPh_(3)/iridium catalyzed diborylation of unactivated primary C(sp^(3))—H bonds using pyrazoles as directing groups was disclosed.This method could tolerate a variety of functional groups,affording a vast array of 1,1-diboron alkanes in moderate to good yields.The synthetic utility of the current method on a gram-scale reaction for further functionalization was also demonstrated.

关 键 词：碳氢键活化 有机硼 合成方法 铱 

分 类 号：O627.31[理学—有机化学]