诺丽酵素中两个新的曲酸类化合物对胰岛素抵抗HepG2细胞葡萄糖摄取的影响  

Two New Kojic Acids from Noni Juice with Glucose Uptake Activity in Insulin-Resistant HepG2 Cells

作　　者：张旭光 张斌 周学明[1] 余章昕[1] 李小宝[1] 陈光英[1] Zhang Xuguang;Zhang Bin;Zhou Xueming;Yu Zhangxin;Li Xiaobao;Chen Guangying(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158;Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs,College of Pharmacy,Hainan Medical University,Haikou 571199)

机构地区：[1]海南师范大学化学与化工学院热带药用资源化学教育部重点实验室热带药用植物化学海南省重点实验室,海口571158 [2]海南医学院药学院海南省热带药用植物研究开发重点实验室,海口571199

出　　处：《有机化学》2022年第4期1252-1255,共4页Chinese Journal of Organic Chemistry

基　　金：海南省重点研发计划(No.ZDYF2019116);国家自然科学基金(Nos.41866005,22177023)资助项目.

摘　　要：从诺丽酵素中分离获得两个新的曲酸类化合物nonikojic A(1)和nonikojic B(2),通过多种现代波谱技术确定了它们的化学结构.并对这2个化合物进行了胰岛素抵抗HepG2细胞葡萄糖摄取的活性评价,结果显示化合物1和2在50μmol/L剂量下均可显著地促进胰岛素抵抗HepG2细胞的葡萄糖摄取,从而改善胰岛素抵抗.Two new kojic acids,nonikojics A and B(1 and 2),were obtained from the water soluble extract of the Noni juice,and their chemical structures were elucidated by comprehensive modern spectroscopic techniques.The effects on glucose uptake of two new compounds were evaluated in insulin-resistant HepG2 cells,and the results indicated that 1 and 2 significantly increased glucose uptake with doses of 50μmol/L and thus improved insulin resistance.

关 键 词：诺丽酵素 曲酸类化合物 葡萄糖摄取 胰岛素抵抗HepG2细胞 

分 类 号：TQ460.1[化学工程—制药化工]