冷冻胚胎移植中替代周期致妊娠期高血压的风险增加及可能机制研究进展  

Research progress on risk increase and possible mechanism of hypertensive disorders in pregnancy caused by replacement cycle during frozen embryo transfer

作　　者：罗星雨(综述) 胥琴 转黎 马艳萍(审校)[2] LUO Xingyu;XU Qin;ZHUAN Li;MA Yanping(Department of Reproductive Medicine,Affiliated Hospital,Kunming University of Science and Technology,Kunming,Yunnan 650093,China;Department of Reproductive Medicine,Yunnan Provincial First People’s Hospital,Kunming 650032,China)

机构地区：[1]昆明理工大学附属医院生殖医学科,650093 [2]云南省第一人民医院生殖医学科,650032

出　　处：《重庆医学》2022年第13期2316-2320,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81660247、81760470);云南省卫生健康委员会医学学科带头人培养计划项目(D-2019018、D-2017022);云南省卫生健康委员会医学后备人才培养计划项目(H2017025)。

摘　　要：冷冻胚胎移植(FET)是人类辅助生殖技术中的重要技术,FET中子宫内膜的准备方法分为自然周期、改良自然周期和替代周期。大量研究发现,使用替代周期孕妇较使用自然周期孕妇发生妊娠期高血压(HDP)的风险增加。目前认为其发生的可能机制与黄体缺失和子宫内膜处于非生理的激素环境有关。该文对替代周期与HDP的相关性及可能机制做一综述。Frozen-thawed embryo transfer(FET)is an important technique in human assisted reproductive technology.The endometrial preparation methods in FET are divided into the natural cycle,modified natural cycle and replacement cycle.A large number of studies have found that pregnant women using replacement cycles have the risk increase of hypertensive disorders in pregnancy(HDP)compared with those using natural cycles.At present,it is believed that the possible mechanism of its occurrence is related to the loss of corpus luteum and the non-physiological hormonal environment of the endometrium.In this paper,the correlation between the replacement cycle and HDP and the possible mechanism are reviewed.

关 键 词：妊娠期高血压 冷冻胚胎移植 替代周期 黄体缺失 松弛素 

分 类 号：R715.5[医药卫生—妇产科学]