Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species  

作　　者：Shuli HUANG Guoliang LI Yongliang PAN Mingjing SONG Jidong ZHAO Xinrong WAN Charles JKREBS Zuoxin WANG Wenxuan HAN Zhibin ZHANG 

机构地区：[1]State Key Laboratory of Integrated Pest Management,Institute of Zoology,Chinese Academy of Sciences,Beijing,China [2]CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing,China [3]School of Medicine,Huzhou University,Huzhou,China [4]Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China(NHC),Beijing Engineering Research Center for Experimental Animal Models of Human Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Science,Beijing,China [5]Department of Zoology,University of British Columbia,Vancouver,British Columbia,Canada [6]Department of Psychology and Program in Neuroscience,Florida State University,Tallahassee,Florida,USA [7]College of Resources and Environmental Sciences,China Agricultural University,Beijing,China

出　　处：《Integrative Zoology》2021年第2期149-159,共11页整合动物学（英文版）

基　　金：This study was supported by the grant from Strategic Priority Research Program of the Chinese Academy of Sciences(XDB11050300);The Inner Mongolia Research Station of Animal Ecology and International Society of Zoological Sciences provided help and assistance for the field works.

摘　　要：It is known that social stress could alter oxytocin(OT)and arginine-vasopressin(AVP)expression in specific regions of brains which regulate the aggressive behavior of small rodents,but the effects of density-induced social stress are still unknown.Brandt’s voles(Lasiopodomys brandtii)are small herbivores in the grassland of China,but the underlying neurological mechanism of population regulation is still unknown.We tested the effects of housing density of Brandt’s voles on OT/AVP system with physical contact(allowing aggression)and without physical contact(not allowing aggression)under laboratory conditions.Then,we tested the effects of paired-aggression(no density effect)of Brandt’s voles on OT/AVP system under laboratory conditions.We hypothesized that high density would increase aggression among animals which would then increase AVP but reduce OT in brains of animals.Our results showed that high housing density induced more aggressive behavior.We found high-densityinduced social stress(with or without physical contact)and direct aggression significantly increased expression of mRNA and protein of AVP and its receptor,but decreased expression of mRNA and protein of OT and its receptor in specific brain regions of voles.The results suggest that density-dependent change of OT/AVP systems may play a significant role in the population regulation of small rodents by altering density-dependent aggressive behavior.

关 键 词：aggression behavior density-dependent stress oxytocin(OT) social stress vasopressin(AVP) 

分 类 号：Q95[生物学—动物学]