妊娠中期孕妇血清糖类抗原、可溶性细胞间黏附分子-1表达与胎盘早剥的相关性  

Correlation of Serum Carbohydrate Antigen,Soluble Intercellular Adhesion Molecule-1 Expression and Placental Abruption in Pregnant Women in the Second Trimester

作　　者：许欣 李宛玲[1] 王冉[1] XU Xin;LI Wan-ling;WANG Ran(First Department of Obstetrics,Nanyang First People’s Hospital,Nanyang,Henan,473001,China)

机构地区：[1]南阳市第一人民医院产一科,河南南阳473000

出　　处：《黑龙江医学》2022年第11期1311-1314,共4页Heilongjiang Medical Journal

摘　　要：目的:观察血清糖类抗原(CA153)、可溶性细胞间黏附分子-1(sICAM-1)在妊娠中期孕妇中的表达,分析二者与胎盘早剥(AP)的关系。方法:回顾性分析2018年1月—2020年3月南阳市第一人民医院完成分娩的61例AP产妇资料,设为AP组。另收集同期60例于医院完成分娩的非AP产妇资料,设为非AP组。设计基线资料填写表,仔细查阅产妇相关资料并记录研究所需基线资料情况,重点比较产妇妊娠中期血清CA153、sICAM-1水平,分析二者表达与AP的关系。结果:AP组血清妊娠相关蛋白A(PAPP-A)、胎盘生长因子(PLGF)水平均低于非AP组,sICAM-1、CA153水平均高于非AP组,差异有统计学意义(t=17.430、11.050,u=7.877、8.139,P<0.05)。回归分析结果显示,妊娠中期血清PAPP-A、PLGF低表达及sICAM-1、CA153过表达与产妇AP发生有关,可能为AP发生的风险因子,差异有统计学意义差异有统计学意义(OR>1,P<0.05)。相关性检验发现,血清CA153、sICAM-1水平之间呈正相关,差异有统计学意义(r>0,P<0.05)。绘制ROC曲线,妊娠中期血清CA153、sICAM-1单独及联合预测AP发生的AUC均>0.80,且当二者的cut-off值分别取88.97 U/mL、800.20μg/L时,可获得最佳预测价值。结论:妊娠中期孕妇血清sICAM-1、CA153表达与AP发生有一定关系,二者过表达可能提示AP高风险,尽早监测孕妇血清sICAM-1、CA153水平,可用于预测AP风险,并指导早期预防。Objective:To observe the expressions of serum carbohydrate antigen(CA153)and soluble intercellular adhesion molecule-1(sICAM-1)in pregnant women in the second trimester,and analyze their relationship with placental abruption(AP).Methods:The data of 61 women with AP who completed delivery in the hospital from January 2018 to March 2020 were retrospec⁃tively analyzed,and they were set as the AP group.The data of 60 non-AP mothers who completed delivery in the hospital during the same period were collected and set as the non-AP group.The baseline information filling form was designed,and the maternal related information was carefully reviewed and the baseline information required for the study was recorded.The levels of serum CA153 and sICAM-1 in the second trimester of pregnancy were compared,and the relationship between their expression and AP was analyzed.Results:The serum levels of pregnancy-associated protein A(PAPP-A)and placental growth factor(PLGF)in the AP group were lower than those in the non-AP group,and the levels of sICAM-1 and CA153 were higher than those in the non-AP group,with statistically significant differences(t=17.430,11.05,P<0.05,u=7.877,8.139,P<0.05).The results of regres⁃sion analysis showed that the low expression of serum PAPP-A and PLGF and the overexpression of sICAM-1 and CA153 in the second trimester of pregnancy were associated with the occurrence of maternal AP,which may be risk factors for the occurrence of AP,the difference was statistically significant(OR>1,P<0.05).Correlation test found that serum CA153 and sICAM-1 levels were positively correlated,the difference was statistically significant(r>0,P<0.05).The ROC curve was drawn.When the AUCs of serum CA153 and sICAM-1 in the second trimester of pregnancy were both greater than 0.80 for predicting the occurrence of AP,and the cut-off values of the two were 88.97 U/ml and 800.20μg/L,respectively,the best predictive value was obtained.Con⁃clusion:The expression of serum sICAM-1 and CA153 in pregnant women in the second trime

关 键 词：妊娠中期 胎盘早剥 糖类抗原 可溶性细胞间黏附分子-1 相关性 

分 类 号：R714.25[医药卫生—妇产科学]