作用于细胞壁的抗真菌药物研究进展  

A review of the study on antifungal drugs acting on cell wall

作　　者：朱信霖 扈东营 陈显振 李新华[3] 蔡良奇[4] 李小静[5] 廖万清 刘晓刚 潘炜华 ZHU Xinlin;HU Dongying;CHEN Xianzhen;LI Xinhua;CAI Liangqi;LI Xiaojing;LIAO Wanqing;LIU Xiaogang;PAN Weihua(Department of Dermatology,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;Shanghai Key Laboratory of Molecule Medical Mycology,Shanghai 200003,China;Department of Dermatology,Taiyuan Central Hospital,Taiyuan 030001,Shanxi,China;Department of Dermatology,First Affiliated Hospital of Xiamen University,Xiamen 361000,Fujian,China;Department of Dermatology,Affiliated Hospital of Hebei Engineering University,Handan 056000,Hebei,China)

机构地区：[1]海军军医大学第二附属医院皮肤科,上海200003 [2]上海市医学真菌分子生物学重点实验室,上海200003 [3]太原市中心医院皮肤科,山西太原030001 [4]厦门大学第一附属医院皮肤科,福建厦门361000 [5]河北工程大学附属医院皮肤科,河北邯郸056000

出　　处：《菌物学报》2022年第6期871-877,共7页Mycosystema

基　　金：国家自然科学基金(81720108026,82072257);上海市科委(20DZ2272900)。

摘　　要：与人类细胞相比,细胞壁为真菌的特有结构,因此作用于细胞壁的抗真菌药物相较于其他类型抗真菌药物而言具有高效、低毒的特点,是迄今为止安全性最高的一类抗真菌药物。本文对作用于细胞壁的抗真菌药物进行综述,根据作用机制及靶点的不同分别介绍葡聚糖合成酶抑制剂、几丁质合成酶抑制剂及糖基磷脂酰肌(glycosylphosphatidylinositol,GPI)锚定蛋白抑制剂,对其进行总结和归纳,为相关药物的研发及将来的临床应用前景提供参考。The antifungal drugs acting on cell wall are a kind of the safest antifungal drugs.Because they have high efficiency and low toxicity as compared with any other antifungal drugs due to that the fungal cells have unique wall structure,which are distinct from human cells.This article reviews the antifungal drugs that act on the cell wall,and introduces preparations inhibiting glucan synthase,inhibiting chitin synthase and inhibiting glycosylphosphatidylinositol-anchored protein according to the different functional mechanisms and antifungal targets,and summarizes the antifungal mechanism,treatment spectrum and the research progress of the antifungal drugs as mentioned above,providing an overview references for the development of related drugs and the application in clinic.

关 键 词：细胞壁 安全性 抗真菌药物 

分 类 号：R978.5[医药卫生—药品]