地佐辛预防瑞芬太尼复合七氟醚麻醉恢复期躁动的临床观察  

Clinical Observation of Dezocine in Preventing Agitation during Recovery from Remifentanil Combined with Sevoflurane Anesthesia

作　　者：冀志林 赵喜英 JI Zhi-lin;ZHAO Xi-ying(Department of Anesthesiology,Ulanqab Second Hospital,Jining,Inner Mongolia,012000,China)

机构地区：[1]乌兰察布市第二医院麻醉科,内蒙古集宁012000

出　　处：《黑龙江医学》2022年第12期1467-1469,共3页Heilongjiang Medical Journal

摘　　要：目的:评价在瑞芬太尼复合七氟醚行全麻手术结束前注射地佐辛对麻醉恢复期躁动的预防作用。方法:选择乌兰察布市第二医院麻醉科2019年5月—2020年5月120例行全身麻醉患者作为研究对象,按随机数表法分为地佐辛组(D组)、对照组(NS组),每组各60例。其中地佐辛组于手术结束前15min通过静脉注射地佐辛5mg,对照组同时期给予静脉注射生理盐水1mL。对麻醉恢复期患者的躁动、镇静及舒适度进行评分并记载,同时记录患者手术结束时、拔管时和拔管后5min三个时间段的心率(HR)和平均动脉压(MAP)。结果:D组躁动评分显著低于NS组,差异有统计学意义(t=8.72,P<0.05);D组镇静评分和舒适度评分显著高于NS组,差异有统计学意义(t=9.721;t=7.904、9.172、9.088,P<0.05);两组患者在手术结束时HR和MAP比较,差异无统计学意义(P>0.05);NS组拔管时和拔管后5min的HR、MAP与手术结束时相比明显升高,差异有统计学意义(P<0.05);D组拔管时HR、MAP较手术结束前显著升高,差异有统计学意义(P<0.05),但拔管后5min的HR、MA与手术结束时,差异无统计学意义(P>0.05),同时D组HR、MAP在拔管时和拔管后5min均高于NS组,差异有统计学意义(P<0.05)。结论:手术结束前予以患者地佐辛干预,不仅可以抑制麻醉恢复期的躁动现象,还可提高患者舒适度,具有较高的临床应用价值。Objective:To evaluate the preventive effect of injecting dezocine before the end of general anesthesia with remifentanil combined with sevoflurane on agitation during anesthesia recovery.Methods:A total of 120 patients undergoing general anesthesia in the hospital from May 2019 to May 2020 were selected as the research subjects,and were randomly divided into dezocine group(group D)and control group(group NS),with 60 cases in each group.The dezocine group was given intravenous injection of dezocine 5 mg 15 min before the end of the operation,and the control group was given intravenous injection of normal saline 1 m L at the same time.The agitation,sedation and comfort of patients during anesthesia recovery were scored and recorded,and heart rate(HR)and mean arterial pressure(MAP)were recorded at the end of surgery,during extubation and 5 min after extubation.Results:The restlessness score of patients in group D was significantly lower than that in group NS,and the difference was statistically significant(t=8.72,P<0.05).The sedation score and comfort score in group D were significantly higher than those in group NS,and the differences were statistically significant(t=9.721,t=7.904,9.172,9.088,P<0.05).There was no statistically significant difference in HR and MAP between the two groups at the end of surgery(P>0.05).HR and MAP at the time of extubation and 5 min after extubation in the NS group were significantly higher than those at the end of the operation,and the difference was statistically significant(P<0.05).HR and MAP in group D at the time of extubation were significantly higher than those before the end of the operation,and the difference was statistically significant(P<0.05).However,there was no statistically significant difference in HR and MA at 5 min after extubation and at the end of surgery(P>0.05).At the same time,HR and MAP in group D were higher than those in group NS at the time of extubation and 5 min after extubation,and the difference was statistically significant(P<0.05).Conclusion:Dezocine in

关 键 词：地佐辛 瑞芬太尼 七氟醚 麻醉 

分 类 号：R614[医药卫生—麻醉学]