芽孢杆菌科来源脂肽的生物合成调控及其在动物生产中的应用  

Biosynthesis regulation of Bacillaceae-derived lipopeptides and its application in animal production

作　　者：姜军坡 杜国霞[3] 杜洁 张红蕾 刘双 王世英 李玮[1] JIANG Junpo;DU Guoxia;DU Jie;ZHANG Honglei;LIU Shuang;WANG Shiying;LI Wei(College of Chemistry and Environmental Science/Key Laboratory of Chemical Biology of Hebei Province/Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education,Hebei University,Baoding 071002,China;College of Life Science/Feed Microbial Technology Innovation Center of Hebei Province,Hebei Agricultural University,Baoding 071001,China;Shijiazhuang Agricultural Comprehensive Administrative Law Enforcement Detachment,Shijiazhuang 050022,China;Hebei Station of Animal Husbandry,Shijiazhuang 050011,China)

机构地区：[1]河北大学化学与环境科学学院/河北省化学生物学重点实验室/教育部药物化学与分子诊断实验室,河北保定071002 [2]河北农业大学生命科学学院/河北省饲用微生物技术创新中心,河北保定071001 [3]石家庄市农业综合行政执法支队,石家庄050022 [4]河北省畜牧总站,石家庄050011

出　　处：《黑龙江畜牧兽医》2022年第11期26-31,共6页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(32101231);河北省重点研发计划项目(20322901D,21322802D);河北省蛋鸡肉鸡产业创新团队废弃物资源化利用岗位项目(HBCT2018150402)。

摘　　要：芽孢杆菌科来源的脂肽(Bacillaceae-derived lipopeptides,BLP)具有抗细菌、抗真菌、抗炎症等活性,因其具有低毒、高效、可生物降解等优点而被认为是抗生素的理想替代物之一,被广泛应用于医药、生物修复、植物病害防治、食品添加剂和化妆品等领域,而其在动物生产中的应用研究尚处于起步阶段。文章综述了BLP的生物合成调控及其在动物生产中的应用,指出了其中存在的问题,提出将发酵饲料技术与BLP应用相结合的发展方向,以期促进BLP在动物生产中的应用。Bacillaceae-derived lipopeptides(BLP) has anti-bacterial, anti-fungal and anti-inflammatory activities. Because of its advantages of low toxicity, high efficiency and biodegradation, it is considered as one of the ideal substitutes for antibiotics, and has been widely used in medicine, biological remediation, plant disease control, food additives, cosmetics and other fields. However, its application in animal production is still in its infancy. This paper reviewed the regulation of BLP biosynthesis and its application in animal production, pointing out the existing problems, and put forward the development direction of combining fermented feed technology with BLP application, in order to promote the application of BLP in animal production.

关 键 词：芽孢杆菌 脂肽 抗生素 生物合成 动物生产 

分 类 号：S816.71[农业科学—饲料科学] TQ936.16[农业科学—畜牧学]