精神障碍患者腰椎骨密度定量CT研究  

Quantitative CT study of bone mineral density of lumbar spine in patients with mental disorders

作　　者：王文斌 耿健[3] 于爱红 程晓光 尚宏元[1,2] 毕凯[1,2] WANG Wen-bin;GENG Jian;YU Ai-hong(Department of Radiology,Beijing Anding Hospital,Capital Medical University,the National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院放射科,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069 [3]北京积水潭医院放射科,北京100035

出　　处：《放射学实践》2022年第7期870-873,共4页Radiologic Practice

基　　金：国家自然科学基金(81971617)。

摘　　要：目的:探讨精神障碍患者腰椎骨密度(BMD)与正常人群的差异,以及影响BMD的相关因素。方法:回顾性选取2021年7月-2022年2月以精神障碍症状在首都医科大学附属北京安定医院住院的600例患者作为患病组,年龄30~86岁,平均49.5岁。618例健康体检人群作为对照组与患病组进行1:1病例对照匹配。所有纳入的研究对象均进行了腰椎定量CT(QCT)骨密度测量。基于性别分层对患病组和对照组之间的体积BMD进行对比分析,并与腰椎BMD相关因素进行多元线性回归分析。结果:精神障碍患者腰椎BMD明显低于健康对照组[(131.0±40.5)mg/cm^(3)vs(147.3±37.0)mg/cm^(3),t=6.16,P<0.001);性别分层下,两性别精神障碍患者BMD均低于健康对照组[男性:(129.3±36.6)mg/cm^(3)vs(152.5±31.3)mg/cm^(3),Z=6.940,P<0.001;女性:(132.6±43.8)mg/cm^(3)vs(142.4±41.2)mg/cm^(3),Z=-2.510,P=0.012]。多元线性回归提示腰椎BMD与患精神类疾病具有显著相关(B=-16.341,P<0.001),与年龄显著相关(B=-2.340,P<0.001)。结论:与健康对照组相比,精神障碍患者BMD明显减低。腰椎BMD与患精神类疾病以及年龄显著相关。Objective:To explore the differences of lumbar bone mineral density(BMD)between patients with mental disorders and the normal population,and the related factors affecting BMD.Methods:From July 2021 to February 2022,600 patients with mental disorders who were hospitalized in Beijing Anding Hospital Affiliated to Capital Medical University were retrospectively selected as the disease group,aged 30~86 years with an average age of 49.51 years.A 1:1 case-control match was performed between 618 healthy people as the control group and the diseased group.All included subjects underwent quantitative CT(QCT)BMD measurement of the lumbar spine.The volumetric BMD between the two groups was compared based on gender stratification and the statistical differences were analyzed.Results:The BMD of lumbar spine in patients with mental disorders was significantly lower than that in healthy controls(131.0±40.5mg/cm^(3) vs 147.3±37.0mg/cm^(3),t=6.16,P<0.001).Under gender stratification,the BMD of lumbar spine in males and females was lower than that of the healthy control group(men:129.3±36.6mg/cm^(3) vs 152.5±31.3mg/cm^(3),Z=6.940,P<0.001;women:132.6±43.8mg/cm^(3) vs 142.4±41.2mg/cm^(3),Z=-2.510,P=0.012),respectively.Multiple linear regression showed that lumbar spine BMD was significantly correlated with mental illness(B=-16.341,P<0.001),and was significantly correlated with age(B=-2.340,P<0.001).Conclusion:Compared with healthy controls,patients with mental disorders have significantly lower BMD.Lumbar spine BMD was significantly associated with mental illness and age.

关 键 词：精神障碍 骨密度 定量CT 

分 类 号：R814.42[医药卫生—影像医学与核医学] R749[医药卫生—放射医学]